Dehydroepiandrosterone sulphate and Mortality in Elderly Men and Women [PDF]
Dehydroepiandrosterone sulfate levels have been inversely related with cardiovascular mortality in men, but findings have been inconsistent, and there are few data in women. We examined the relationship between baseline circulating dehydroepiandrosterone
Khaw, Kay-Tee, Trivedi, Daksha
core
Dehydroepiandrosterone protects the microcirculation of muscle flaps from ischemia-reperfusion injury by reducing the expression of adhesion molecules [PDF]
Adhesion molecules contribute to ischemia-reperfusion injury by increasing the endothelial adhesion and extravasation of leukocytes. Scientific evidence suggests that presurgical treatment with dehydroepiandrosterone may protect the microvasculature ...
AYHAN, MEHMET SÜHAN +4 more
core +1 more source
Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu +5 more
wiley +1 more source
Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization [PDF]
Kevin N Keane,1,2 Peter M Hinchliffe,2 Navid Namdar,2 Jason L Conceicao,2 Philip Newsholme,1 John L Yovich1,2 1School of Biomedical Sciences, Curtin Health Innovation Research Institute – Biosciences, Curtin University, 2PIVET Medical Centre ...
Hinchliffe PM +5 more
core
X-RAY POWDER DIFFRACTION IN QUALITY CONTROL OF MEDICINES
X-ray powder diffraction is one of the methods used for detection and analysis of polymorphic forms of pharmaceutical substances. The article elucidates the concept of polymorphism, briefly explains physical characteristics of this phenomenon, conditions
V. S. Kuzmin +2 more
doaj +1 more source
Sugar Amino Acid Linkers for the Design of [18F]SiFA‐PSMA Radioligands
Sugar amino acid (SAA) linkers were incorporated into silicon‐fluoride‐acceptor (SiFA)‐prostate‐specific membrane antigen (PSMA) radioligands to modulate pharmacokinetic properties while preserving efficient 18F isotopic exchange radiolabeling. Furanose‐based SAAs outperformed pyranose analogues, enabling specific tumor visualization by PET despite ...
Narendar R. Gade +5 more
wiley +1 more source
The effect of dehydroepiandrosterone on coronary blood flow in prepubertal anaesthetized pigs [PDF]
Extensive research suspecting an association between plasma levels of dehydroepiandrosterone and the risk of coronary heart disease has not been conclusive.
Mary DA +11 more
core +1 more source
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen +14 more
wiley +1 more source
CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling [PDF]
CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5 alpha-androstane-3 beta,17 beta-diol (3 beta-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones ...
Axelson, M, +7 more
core +1 more source
Circulating Sex Hormone Levels and Survival in Men With Esophageal Squamous Cell Carcinoma
ABSTRACT Background Men with esophageal squamous cell carcinoma (ESCC) have worse survival than women, a disparity in which sex hormones may play a role. Yet, whether circulating sex hormone levels are associated with survival in ESCC remains largely unexplored.
Zhiqiang Liu +7 more
wiley +1 more source

