Results 91 to 100 of about 39,056 (236)

X-RAY POWDER DIFFRACTION IN QUALITY CONTROL OF MEDICINES

Регуляторные исследования и экспертиза лекарственных средств, 2018
X-ray powder diffraction is one of the methods used for detection and analysis of polymorphic forms of pharmaceutical substances. The article elucidates the concept of polymorphism, briefly explains physical characteristics of this phenomenon, conditions
V. S. Kuzmin, V. V. Chernyshev, A. I. Luttseva   +2 more
doaj   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Effects of DHEA and DHEAS in Neonatal Hypoxic–Ischemic Brain Injury

Antioxidants
Neonatal brain injury remains a significant issue with limited treatment options. This study investigates the potential of the endogenous neurosteroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) as neuroprotective agents, building on ...
Elena Mayer, Ira Winkler, Eva Huber, Martina Urbanek, Ursula Kiechl-Kohlendorfer, Elke Griesmaier, Anna Posod   +6 more
doaj   +1 more source

Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters

Frontiers in Pharmacology, 2018
Neurosteroids, comprising pregnane, androstane, and sulfated steroids can alter neuronal excitability through interaction with ligand-gated ion channels and other receptors and have therefore a therapeutic potential in several brain disorders.
Markus Grube, Paul Hagen, Gabriele Jedlitschky   +2 more
doaj   +1 more source

Inonotus obliquus Ameliorates Metabolic Dysfunction and Attenuates Obesity by Enriching Enterococcus casseliflavus

Food Frontiers, Volume 7, Issue 4, July 2026.
Inonotus obliquus mitigates obesity through the targeted enrichment of intestinal Enterococcus casseliflavus (EC). EC facilitates thermogenesis in adipose tissues, augments energy expenditure, enhances systemic metabolic homeostasis, and diminishes low‐grade inflammation.
Xiao Sun, Xuliang Wei, Meng Dong, Haoyang Liu, Tengyu Zhu, Yangming Zhang, Longhui Wang, Yongchun Li, Hongde Xu   +8 more
wiley   +1 more source

Biotransformation of dehydroepiandrosterone (DHEA) by environmental strains of filamentous fungi

, 2017
Study on the ability of selected filamentous fungus species to transform dehydroepiandrosterone was performed (DHEA) and interesting DHEA derivatives were obtained with high yield.
Tomasz Janeczko, Monika Urbaniak, Edyta Kostrzewa-Susłow, Łukasz Stępień, Anna Kancelista, Monika Dymarska, Ewa Kozłowska   +6 more
core   +1 more source

Correlation Analysis of Hypothalamic-Pituitary-Adrenal Axis Hormone Levels in Hair before Stroke Onset and Mood Disorders after Stroke

康复学报
ObjectiveTo explore the expression of hypothalamic-pituitary-adrenal (HPA) axis related hormones such as cortisol (F), cortisone (E) and dehydroepiandrosterone (DHEA) in hair before the onset of stroke and their correlation with post-stroke mood ...
WANG Tiantian, JIA Yuanyuan, QI Deyi, DENG Huihua, MENG Dianhuai   +4 more
doaj  

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source