Results 51 to 60 of about 635,949 (288)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

New Stability Results for Abstract Fractional Differential Equations with Delay and Non-Instantaneous Impulses

open access: yesMathematics, 2023
This research delves into the field of fractional differential equations with both non-instantaneous impulses and delay within the framework of Banach spaces.
Abdellatif Benchaib   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Further results on local stability of REM algorithm with time-varying delays [PDF]

open access: yes, 2005
This letter presents some further results on the local stability in equilibrium for Internet congestion control algorithm proposed by Low et al. (IEEE/ACM Transactions on Networking, 1999).
Gao, H, Guan, X, Lam, J, Wang, C
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Feedback stabilization of dynamical systems with switched delays

open access: yes, 2012
We analyze a classification of two main families of controllers that are of interest when the feedback loop is subject to switching propagation delays due to routing via a wireless multi-hop communication network. We show that we can cast this problem as
D'Innocenzo, Alessandro   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

On Delay-Range-Dependent Stochastic Stability Conditions of Uncertain Neutral Delay Markovian Jump Systems

open access: yesJournal of Applied Mathematics, 2013
The delay-range-dependent stochastic stability for uncertain neutral Markovian jump systems with interval time-varying delays is studied in this paper. The uncertainties under consideration are assumed to be time varying but norm bounded.
Xinghua Liu, Hongsheng Xi
doaj   +1 more source

Stability of Switched Systems with Time-Varying Delays under State-Dependent Switching

open access: yesMathematics, 2022
This paper studies the stability of linear switched systems with time-varying delays and all unstable subsystems. According to the largest region function strategy, the state-dependent switching rule is designed.
Chao Liu, Xiaoyang Liu
doaj   +1 more source

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