Results 51 to 60 of about 47,314 (311)

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

On the Oscillation of the Generalized Food-Limited Equations with Delay

Aceh International Journal of Science and Technology, 2012
The objective of the paper is to find conditions for the oscillation of the food-limited equation. We established conditions for the oscillation of all solutions of the generalized foodlimited equation by transforming the equation to a non-linear delay ...
Bamaina M. Muhammad, Yusuf Haruna, Bala M. Abdulhamid   +2 more
doaj  

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Linear Analysis of an Integro-Differential Delay Equation Model

International Journal of Differential Equations, 2018
This paper presents a computational study of the stability of the steady state solutions of a biological model with negative feedback and time delay. The motivation behind the construction of our system comes from biological gene networks and the model ...
Anael Verdugo
doaj   +1 more source

Parabolic differential equations with bounded delay

Journal of Evolution Equations, 2022
AbstractWe show the continuous dependence of solutions of linear nonautonomous second-order parabolic partial differential equations (PDEs) with bounded delay on coefficients and delay. The assumptions are very weak: only convergence in the weak-* topology of delay coefficients is required. The results are important in the applications of the theory of
Marek Kryspin, Janusz Mierczyński
openaire   +2 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

On stability and boundedness of solutions of a certain fourth-order delay differential equation

International Journal of Mathematics and Mathematical Sciences, 1989
Using a Razumikhin - type theorem, we deduce sufficient conditions that guarantee the uniform asymptotic stability and boundedness of solutions of a scalar real fourth-order delay differential equation.
Emmanuel O. Okoronkwo
doaj   +1 more source

Dynamics of Delay Differential Equations with Their Applications

Abstract and Applied Analysis, 2013
Delay differential equations have attracted a rapidly growing attention in the field of nonlinear dynamics and have become a powerful tool for investigating the complexities of the real-world problems such as infectious diseases, biotic population, neuronal networks, and even economics and finance.When employing delay differential equations to solve ...
Chuangxia Huang, Zhiming Guo, Zhichun Yang, Yuming Chen   +3 more
openaire   +4 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source