Results 71 to 80 of about 172,224 (315)
International Journal of Nanomedicine, 2021 Jiaojiao Cao,1,* Jie Huang,1,* Shuangying Gui,1,2 Xiaoqin Chu1,2 1Department of Pharmaceutics, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic of China; 2Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei ...
Cao J, Huang J, Gui S, Chu X
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]
, 1982 The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi +47 more
core +1 more source
Toxins, 2018 The insecticidal crystal proteins from Bacillus thuringiensis (Bt) are widely-used biopesticides that are used both as Bt spore-crystal preparations in sprayable formulations and as activated toxins in genetically modified (GM) plants.
Angelika Hilbeck +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Frontiers in Public Health, 2014 Aedes aegypti L., the primary carrier for viruses causing dengue, chikungunya and yellow fever is widespread over large areas of the tropics and subtropics.
Sarita eKumar +3 more
doaj +1 more source
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
, 2017 Most physicists do not have patience for reading long and obscure interpretation arguments and disputes. Hence, to attract attention of a wider physics community, in this paper various old and new aspects of quantum interpretations are explained in a ...
Nikolic, H.
core +1 more source
Experimentally-calibrated population of models predicts and explains inter-subject variability in cardiac cellular\ud electrophysiology [PDF]
, 2013 Cellular and ionic causes of variability in the electrophysiological activity of hearts from individuals of the same species are unknown. However, improved understanding of this variability is key to enable prediction of the response of specific hearts ...
Britton, O.J. +6 more
core +1 more source