Results 41 to 50 of about 1,174,028 (302)

Characteristics of four natural poliovirus type 1 variants with six-nucleotide deletion (2,783–2,788 nt) in the VP1 region

Microbiology Spectrum
Since the establishment of the Chinese acute flaccid paralysis (AFP) case surveillance system in 1999, around 7,200 strains of poliovirus (PV) type 1 have been identified and isolated.
Jie Lin, Lei Zhou, Chenglin Zhu, Jinhang Wei, Bo Lv, Yuan Si, Shuangli Zhu, Tianjiao Ji, Dongyan Wang, Qian Yang, Jinbo Xiao, Lan Yang, Kaitao Xiao, Kexin Shao, Yong Zhang, Dongmei Yan   +15 more
doaj   +1 more source

Detection of a Cryptic 25 bp Deletion and a 269 Kb Microduplication by Nanopore Sequencing in a Seemingly Balanced Translocation Involving the LMLN and LOC105378102 Genes

Frontiers in Genetics, 2022
Preimplantation genetic testing plays a critical role in enabling a balanced translocation carrier to obtain the normal embryo. Identifying the precise breakpoints for the carriers with phenotypic abnormity, allows us to reveal disrupted genes.
Yanan Wang, Zhenhua Zhao, Xinyu Fu, Shufang Li, Qiuyan Zhang, Xiangdong Kong   +5 more
doaj   +1 more source

Genome- and transcriptome-assisted development of nuclear insertion/deletion markers for Calanus species (Copepoda: Calanoida) identification [PDF]

, 2014
Copepods of the genus Calanus are key zooplankton species in temperate to arctic marine ecosystems. Despite their ecological importance, species identification remains challenging.
Poortvliet, Marloes, Hoarau, Galice, Smolina, Irina, Smolina, I, Kollias, Spyros, Castellani, Claudia, Kollias, S., Blanco-Bercial, L., Nielsen, Torkel Gissel, Hoarau, Galice Guillaume, Castellani, C, Poortvliet, M, Kollias, S, Møller, Eva, Poortvliet, M., Lindeque, PK, Hoarau, G., Lindeque, Penelope, Castellani, C., Nielsen, TG, Hoarau, G, Blanco-Bercial, Leocadio, Møller, E.F., Lindeque, P., Smolina, I., Møller, EF, Møller, Eva Friis, Møller, E. F., Blanco-Bercial, L, Nielsen, Torkel   +29 more
core   +1 more source

Investigation of the role of t(4;6) and 6q15 deletion in prostate cancer development and progression [PDF]

, 2010
PhDThe recent identification of TMPRSS2:ETS gene fusions highlighted the importance of chromosomal rearrangement and fusion gene development in prostate tumourigenesis.
Shan, Ling
core   +4 more sources

From karyotypes to precision genomics in 9p deletion and duplication syndromes

HGG Advances, 2022
While 9p deletion and duplication syndromes have been studied for several years, small sample sizes and minimal high-resolution data have limited a comprehensive delineation of genotypic and phenotypic characteristics.
Eleanor I. Sams, Jeffrey K. Ng, Victoria Tate, Ying-Chen Claire Hou, Yang Cao, Lucinda Antonacci-Fulton, Khadija Belhassan, Julie Neidich, Robi D. Mitra, F. Sessions Cole, Patricia Dickson, Jeffrey Milbrandt, Tychele N. Turner   +12 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Isolation and Identification of Subgroup J Avian Leukosis Virus Inducing Multiple Systemic Tumors in Parental Meat-Type Chickens

Frontiers in Veterinary Science, 2021
Avian leukosis virus (ALV) continues evolving to obtain new genomic characters to enhance its pathogenicity. In the present study, an ALV-J strain LH20180301 was isolated from broiler breeder chickens that reached the speak of paralyzation before 20-week-
Ning Cui, Xuezhi Cui, Qinghua Huang, Shaohua Yang, Shuai Su, Chuantian Xu, Jianhe Li, Wenfeng Li, Chao Li   +8 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

A naturally occurring NS1 variant with effector domain deletion gains growth advantages in influenza virus infection

Emerging Microbes and Infections
High pathogenicity avian influenza virus (HPAIV) poses major threats to both poultry health and public safety. The viral nonstructural protein 1 (NS1) plays a crucial role in counteracting innate immunity.
Ruei-Sheng Tsai, Jun-Yuh Tsai, Yun-Ting Chung, Ching-Yu Tseng, Guan-Ru Liao, Randy A. Albrecht, Chih-Ying Kuan, Rei-Lin Kuo, Shan-Chia Ou, Wei-Li Hsu   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source