Results 31 to 40 of about 93,878 (266)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Modulating delirium through stimulation (MoDeSt): study protocol for a randomized, double-blind, sham-controlled trial assessing the effect of postoperative transcranial electrical stimulation on delirium incidence

Trials
Background Postoperative delirium (POD) is the most common neurological adverse event among elderly patients undergoing surgery. POD is associated with an increased risk for postoperative complications, long-term cognitive decline, an increase in ...
Sophie Leroy, Viktor Bublitz, Ulrike Grittner, Robert Fleischmann, Falk von Dincklage, Daria Antonenko   +5 more
doaj   +1 more source

Dose⁃response relationship between delirium duration and post⁃intensive care syndrome⁃cognitive impairment

Huli yanjiu, 2023
ObjectiveTo explore the dose⁃response relationship between delirium duration and post⁃intensive care syndrome⁃cognitive impairment（PICS⁃CI）.MethodsA total of 271 critically ill patients from two tertiary grade A comprehensive hospitals in Fujian province
WEI Yueqing, WU Tingting, YI Bilan, LI Hong   +3 more
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Artificial Intelligence–Based Online Symptom Assessment Tools for Systemic Lupus Erythematosus Diagnosis: Patient Perspectives

Arthritis Care &Research, EarlyView.
Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein, Jennifer L. F. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source

Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study

BMJ Open
Objectives Neurogranin (Ng) has a role in synaptic plasticity and is considered a biomarker of synaptic dysfunction, a process hypothesised to be important in delirium. Few studies examining Ng in delirium exist, with mixed findings.
Henrik Zetterberg, Kaj Blennow, Dag Aarsland, Marius Myrstad, Mathias N P Hella, Nathalie B Halaas, Hogne Soennesyn, Anne K Bergland, Hanne B Hetland, Audun O Vik-Mo, Ane-Victoria Idland, Christian T Pollmann, Bjørn E Neerland, Leiv O Watne   +13 more
doaj   +1 more source

In-hospital delirium risk assessment, diagnosis and management; medications to avoid

Italian Journal of Medicine, 2013
Background: Delirium is a common, but potentially preventable complication of acute illness that is associated with important adverse outcomes including increased length of hospital admission, risk of dementia and admission to long-term care. In-hospital
Andrew Clegg, John Young
doaj   +1 more source

Delirium in Internal Medicine Departments in a Tertiary Hospital in Israel: Occurrence, Detection Rates, Risk Factors, and Outcomes

Frontiers in Medicine, 2020
Background: The aim of the study was to assess the occurrence rate of delirium among elderly hospitalized patients in the medicine wards of a large tertiary hospital, to identify risk factors, and to evaluate the diagnostic rate for delirium among the ...
Nirit Tzur Efraim, Nirit Tzur Efraim, Evgeniya Zikrin, Evgeniya Zikrin, David Shacham, David Shacham, Dori Katz, Dori Katz, Evgeni Makulin, Evgeni Makulin, Leonid Barski, Leonid Barski, Lior Zeller, Lior Zeller, Carmi Bartal, Carmi Bartal, Tamar Freud, Svetlana Lebedinski, Yan Press, Yan Press, Yan Press, Yan Press, Yan Press   +22 more
doaj   +1 more source

Delirium education for geriatric patients and their families: A quality improvement initiative✰

Aging and Health Research, 2023
Delirium affects up to 50% of hospitalized older adults, contributing to poor outcomes. Family members can be engaged in delirium identification, prevention, and management.
Serena P. Wong, Jennifer Tu, Stuart Downie, Mitchell T. Heflin, Shelley R. McDonald, Mamata Yanamadala   +5 more
doaj   +1 more source

Historical Foundation and Practical Guideline for Ferroelectric Switching Kinetic Studies

Advanced Functional Materials, EarlyView.
The P and U pulses in the conventional PUND measurements are not identical because of the interplay between switching current and the measurement circuit components. This circuit effect can lead to a shift in polarization transients and misinterpreted physics in the switching kinetics.
Yi Liang, Pat Kezer, John T. Heron
wiley   +1 more source