Results 51 to 60 of about 216,498 (359)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Prevalence of delirium in intensive care patients and association with sedoanalgesia, severity and mortality

Revista Gaúcha de Enfermagem, 2020
Objective: To establish the prevalence of delirium and its subsyndrome in intensive care and to associate it with the use of sedative and analgesia, severity and mortality.
Alessandra Soler Bastos, Lúcia Marinilza Beccaria, Daniele Cristiny da Silva, Taís Pagliuco Barbosa   +3 more
doaj   +2 more sources

Early Delirium Assessment for Hospitalized Older People in Indonesia: a Systematic Review [PDF]

, 2016
Background: Due to the increasing risk of getting co-morbidity and frailty, older people tend to be prone to hospitalization. Hospitalization in older people brings many adverse effects.
Chen, C. (Ching-Min), Saifullah, A. D. (Azam)   +1 more
core  

Acetylcholinesterase activity measurement and clinical features of delirium [PDF]

, 2016
Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum AChE activity and (1) clinical features of delirium and (2) outcomes, among older hospital ...
Gladman, J.R.F., Jackson, T.A., Lord, J.M., Maclullich, A.M.J., Moorey, H.C., Sheehan, B.   +5 more
core   +4 more sources

Exploring Patients’ Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial

Arthritis Care &Research, EarlyView.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source

Normative characterization of age-related periodic and aperiodic activity in resting-state real-world clinical EEG recordings

Frontiers in Aging Neuroscience
IntroductionThe relevance of electroencephalographic (EEG) biomarkers is increasing, as advancements in spectral analysis enable computational decomposition of complex neural signals into quantitative EEG (qEEG) parameters. Especially the differentiation
Sophie Leroy, Sophie Leroy, Sophie Leroy, Viktor Bublitz, Falk von Dincklage, Daria Antonenko, Robert Fleischmann, Robert Fleischmann   +7 more
doaj   +1 more source

Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients. [PDF]

, 2018
In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a
Adler, Deb, Alban, Christopher, Bondi, Mark, Braun, Michelle, Cagigas, Xavier, Daven, Morgan, Denney, Robert L, Drozdick, Lisa, Foster, Norman L, Golden, Tamara, Hwang, Ula, Iverson, Grant, Ivey, Laurie, Kramer, Joel, Lacritz, Laura, Lantz, Melinda, Latts, Lisa, Ling, Shari M, Malone, Michael, Maria Lopez, Ana, Martin-Plank, Lori, Maslow, Katie, McConnel, Charles E, Melady, Don, Messer, Melissa, Meyers, John, Most, Randi, Norris, Margaret P, Perry, William, Pliskin, Neil, Roebuck-Spencer, Tresa, Shafer, David, Silver, Cheryl, Silverberg, Nina, Thomas, Colin M, Thornhill, Laura, Tsai, Jean, Vakharia, Nirav, Waters, Martin   +38 more
core   +2 more sources

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, EarlyView.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Delirium incidence and risk factors in adult critically ill patients in Saudi Arabia

Journal of Emergencies, Trauma and Shock, 2019
Background: Delirium in intensive care units (ICUs) is associated with long ICU stay, long hospital stay and increased costs of treatment. Unfortunately, delirium in ICU is significantly underestimated and overlooked by healthcare providers.
Akram Mohammad Rasheed, Mohammad Amirah, Mohammad Abdallah, Adel M Awajeh, P J Parameaswari, Abdulrhman Al Harthy   +5 more
doaj   +1 more source

Effect of postoperative delirium after cardiovascular surgery on 5-year mortality

JA Clinical Reports, 2023
Introduction Postoperative delirium is a common complication after cardiovascular surgery. A meta-analysis revealed that postoperative delirium was associated with cognitive decline and dementia, which may affect long-term mortality. However, few studies
Chisaki Yokoyama, Kenji Yoshitnai, Soshiro Ogata, Satsuki Fukushima, Hitoshi Matsuda   +4 more
doaj   +1 more source