Results 101 to 110 of about 803,603 (305)

Policy, power, stigma and silence: exploring the complexities of a primary mental health care model in a rural South African setting [PDF]

, 2016
The Movement for Global Mental Health’s (MGMH) efforts to scale up the availability of mental health services have been moderately successful. Investigations in resource-poor countries like South Africa have pointed to the value of an integrated primary ...
Burgess, Rochelle Ann
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Is the content of guidelines/pathways a barrier for the integration of palliative Care in Chronic Heart Failure (CHF) and chronic pulmonary obstructive disease (COPD)? A comparison with the case of cancer in Europe

BMC Palliative Care, 2017
Background There is a notable inequity in access to palliative care (PC) services between cancer and Chronic Heart Failure (CHF)/Chronic Obstructive Pulmonary Disease (COPD) patients which also translates into discrepancies in the level of integration of
Naouma Siouta, Karen Van Beek, Sheila Payne, Lukas Radbruch, Nancy Preston, Jeroen Hasselaar, Carlos Centeno, Johan Menten   +7 more
doaj   +1 more source

RESOURCE ALLOCATION, FINANCING AND SUSTAINABILITY IN THE HEALTH SECTOR. ESRI Research Bulletin 2010/3/1 [PDF]

, 2010
The focus on acute, episodic care in the conventional health-care model fails to provide adequately for changing health-care needs arising from increased longevity and increasing prevalence of chronic disease.
Brick, Aoife, Nolan, Anne, O’Reilly, Jacqueline, Smith, Samantha   +3 more
core  

Baseline assessment of adult and adolescent primary care delivery in Rwanda: an opportunity for quality improvement [PDF]

, 2014
Background: As resource-limited health systems evolve to address complex diseases, attention must be returned to basic primary care delivery. Limited data exists detailing the quality of general adult and adolescent primary care delivered at front-line ...
Anatole, Manzi, Cyamatare, Felix R, Drobac, Peter, Gupta, Neil, Hagenimana, Marc, Hedt-Gauthier, Bethany L, Hirschhorn, Lisa R, Mezzacappa, Catherine, Ndayisaba, Aphrodis, Nkikabahizi, Fulgence, Nzeyimana, Bonaventure, Vasan, Ashwin   +11 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Collaboration, coordination and communication as facilitators of transitions for patients with advanced cancer: a scoping review linked to the Pal-Cycles project

BMC Palliative Care
Background Person-centred care is becoming increasingly recognised as an important element of palliative care. The current review syntheses evidence in relation to transitions in advanced cancer patients with palliative care needs.
Rachel Louise Hooley, Sheila Payne, Dunja Begovic, Juan Esteban Correa-Morales, Andrew Harding, Jeroen Hasselaar, Nancy Preston   +6 more
doaj   +1 more source

Models of competent care for people with intellectual/developmental disabilities [PDF]

, 2015
This literature review aims to review research studies that have investigated strategies for care coordination through various healthcare delivery models for intellectually/developmentally disabled population (I/DD). This brief offers a set of principles
Singh, Jogeshwar
core  

The role of nurse specialists in the delivery of integrated diabetes care: a cross-sectional survey of diabetes nurse specialist services [PDF]

, 2017
Objectives: International evidence suggests the diabetes nurse specialist (DNS) has a key role in supporting integrated management of diabetes. We examine whether hospital and community DNS currently support the integration of care, examine regional ...
Barrett, Julie, Kearney, Patricia M., McHugh, Sheena M., Murphy, Katie, Riordan, Fiona   +4 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source