Results 101 to 110 of about 2,159,566 (363)
Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourceMachine learning models predicting inpatient falls
Scientific ReportsAccurate prediction of inpatient fall risk is crucial for preventing injuries and improving patient safety in hospitals. The widely used Hester-Davis score (HD) lacks precision, highlighting the need for more advanced models.Hojjat Salehinejad, Ricky Rojas, Kingsley Iheasirim, Paul Takahashi, Bijan J. Borah, Mohammed Yousufuddin +5 moredoaj +1 more sourceIntein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more sourceThe organisation and delivery of health improvement in general practice and primary care: a scoping study [PDF]
, 2015 Background
This project examines the organisation and delivery of health improvement activities by and within general practice and the primary health-care team. The project was designed to examine who delivers these interventions, where they are located,, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abdullahi, Acheson, Adab, Adams, Agomo, Alshamsan, Amato, Anderson, Anderson, Anderson, Anderson, Anderson, Anokye, Anokye, Arksey, Ashenden, Austoker, Aveyard, Baggott, Baggott, Baker, Balkau, Bane, Banks, Baraitser, Baric, Barlow, Barnett-Page, Barnum, Barr, Barter-Godfrey, Bauld, Bauld, Baumann, Begh, Bell, Bertholet, Blenkinsopp, Boehler, Boland, Bond, Bond, Boyce, Boyd, Brabin, Brankin, Brotons, Brown, Bryan, Bryans, Bryar, Buckley, Buffels, Bunn, Burrows, Cahill, Calvert, Campbell, Campbell, Campbell, Campbell, Campbell, Cardona-Morrell, Carlisle, Carlisle, Chapple, Chauhan, Checkland, Checkland, Chew-Graham, Chiu, Chiu, Cioffe, Clamp, Clark, Cleland, Cockman, Coleman, Coleman, Coleman, Coleman, Coleman, Coleman, Coleman, Coleman, Connell, Connolly, Copello, Coulter, Coulter, Craigie, Crilly, Cupples, Cupples, Dabrera, Dachsel, Dalton, Damery, Damery, Davey, Daykin, de Lusignan, De Maeseneer, Dickinson, Dixon, Dixon-Woods, Dixon-Woods, Donyai, Doran, Doran, Dowell, Drennan, Drennan, Duaso, Dugdill, Dunkley, D’Souza, Ebrahim, Eilbert, Elley, Ellins, Emmett, Emond, Epstein, Fagan, Feder, Felce, Fisher, Fitzpatrick, Fleetcroft, Fleming, Flodgren, Freeman, Frenk, Froon, Getz, Gibbons, Gilbert, Gill, Gillam, Gillam, Gillam, Gillam, Gillespie, Goldsmith, Goodwin, Goodwin, Gordon, Goyder, Graffy, Graffy, Graham, Gravelle, Gray, Greasley, Greaves, Griffin, Griffiths, Griffiths, Grossman, Guassora, Hall, Hall, Hankey, Hanney, Harari, Harding, Harding, Harris, Hart, Herbert, Hewitson, Hillsdon, Hillsdon, Hippisley-Cox, Hoddinott, Hoddinott, Hogan, Hogg, Holden, Holt, Hooper, Horgan, Hoskins, Howse, Hughes, Hunter, Ibbotson, Jackson, Jackson, Janssen, Jenkins, Jinks, Joshi, Joyce, Kai, Kane, Kaner, Kaner, Kaner, Kaner, Kendrick, Kendrick, Kennedy, Kennedy, Kharicha, Khunti, Kirkcaldy, Knussen, Koopman, Krass, Kringos, Krogsbøll, Krumholz, Kumar, Kumar, Kyaw, Lai, Lamb, Lambert, Lamden, Lancaster, Langham, Langham, Lavin, Lawal, Lawlor, Lawlor, Laws, Laws, Lawton, Le Grand, Leavell, Leavell, Lennox, Lewis, Li, Lindsay, Little, Lloyd, Logan, Lowe, Lowther, Ma, MacAuley, Macdonald, Macpherson, Magee, Mant, Marcus, Marks, Marks, Marmot, Marshall, Marteau, Martin, Martin-Misener, Maryon-Davis, Mason, Mathews, Maynard, Mays, McAlister, McCaig, McCluskey, McCormick, McDonald, McDonald, McDonald, McDonald, McEwen, McEwen, McEwen, McEwen, McIlfatrick, McInnes, McKenna, McLean, McNaughton, McNulty, McNulty, McRobbie, Miller, Millett, Millett, Milne, Mold, Moon, Morgan, Morris, Muir, Munro, Murray, Murray, Murray, Nicholas, Nield, Nissen, Norbury, Norris, Ogden, Ogden, Okereke, Orozco, O’Donnell, O’Neill, Parry, Patel, Patel, Pavey, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Perkins, Peto, Pieterse, Pilnick, Pilnick, Pimenta, Plochg, Pomerleau, Pope, Pratt, Price, Pritchard, Prost, Raftery, Rapley, Raw, Reilly, Rennard, Rice, Rice, Richards, Ritchie, Robertson, Robson, Robson, Romeo, Ronckers, Rychetnik, Saha, Sahota, Sanderson, Santer, Santer, Sargeant, Schroeder, Scriven, Scullard, Secker-Walker, Seedhouse, Senok, Sharp, Silagy, Simmons, Simpson, Sinclair, Sippel, Smeeth, Smeeth, Smeeth, Smith, Smith, Soljak, Soljak, Spice, Springett, Starfield, Starfield, Stead, Stead, Subramanian, Summers, Sutherland, Sweeney, Syson-Nibbs, Taggart, Taket, Tannahill, Taylor, Thomas, Thomas, Thorlby, Toon, Trueman, Tsianakas, Tudor-Hart, Tulloch, Turton, Twardella, Twigg, Ulbricht, van Gerwen, Van Lerberghe, Vogt, Vogt, Wainwright, Walker, Waller, Wanless, Ward, Warren, Waters, Watson, Watson, Watson, Watt, Watt, Watt, Weiler, Weiss, West, White, White, Whitehead, Whitehead, Wilkes, Wilkinson, Wilson, Wilson, Wonderling, Wood, Woodrow, Woolthuis, Wynn, Young, Zuvekas, Zwar +476 morecore +3 more sourcesClass IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio +13 morewiley +1 more source
