Results 81 to 90 of about 3,396,568 (293)

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundIn comparison to warfarin, non–vitamin K antagonist oral anticoagulants (NOACs) have the advantages of ease of dosing, fewer drug interactions, and lack of need for ongoing monitoring. We sought to evaluate whether these advantages translate to
Xiaoxi Yao, Neena S. Abraham, G. Caleb Alexander, William Crown, Victor M. Montori, Lindsey R. Sangaralingham, Bernard J. Gersh, Nilay D. Shah, Peter A. Noseworthy   +8 more
doaj   +1 more source

Physical distancing for care delivery in health care settings: Considerations and consequences. [PDF]

Am J Infect Control, 2021
Parmasad V, Keating JA, Carayon P, Safdar N.   +3 more
europepmc   +1 more source

Assessing Health Care Interventions via an Interrupted Time Series Model: Study Power and Design Considerations [PDF]

arXiv, 2018
The delivery and assessment of quality health care is complex with many interacting and interdependent components. In terms of research design and statistical analysis, this complexity and interdependency makes it difficult to assess the true impact of interventions designed to improve patient health care outcomes.
arxiv  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Creating a Practical Transformational Change Management Model for Novel Artificial Intelligence–Enabled Technology Implementation in the Operating Room

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2022
Objective: To identify change management (CM) strategies for implementing novel artificial intelligence and similar novel technologies in operating rooms and create a new CM model for future trials and applications inspired by the abovementioned ...
Tianqi G. Smith, PhD, Hamid Norasi, PhD, Kelly M. Herbst, BEd, Michael L. Kendrick, MD, Timothy B. Curry, MD, PhD, Teodor P. Grantcharov, MD, PhD, Vanessa N. Palter, MD, PhD, M. Susan Hallbeck, PhD, Sean P. Cleary, MD   +8 more
doaj  

The use of experimental vignette studies to identify drivers of variations in the delivery of health care: a scoping review. [PDF]

BMC Med Res Methodol, 2021
Sheringham J, Kuhn I, Burt J.
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Depression and Anxiety Among Patients on Chronic Opioid Therapy

Health Services Research & Managerial Epidemiology, 2018
Background: Chronic noncancer pain (CNCP) and chronic opioid therapy (COT) commonly coexist with comorbid depression and anxiety. We investigated the prevalence of depression and anxiety and their correlates at the time of controlled substance agreement (
Muhamad Y. Elrashidi, Lindsey M. Philpot, Priya Ramar, William B. Leasure, Jon O. Ebbert   +4 more
doaj   +1 more source