Results 51 to 60 of about 2,303,071 (294)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A property of isometric mappings between dual polar spaces of type DQ(2n,K) [PDF]

open access: yes, 2010
Let f be an isometric embedding of the dual polar space Delta = DQ(2n, K) into Delta' = DQ(2n, K'). Let P denote the point-set of Delta and let e' : Delta' -> Sigma' congruent to PG(2(n) - 1, K') denote the spin-embedding of Delta'.
De Bruyn, Bart
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Beyond Logarithmic Corrections to Cardy Formula

open access: yes, 2011
As shown by Cardy modular invariance of the partition function of a given unitary non-singular 2d CFT with left and right central charges c_L and c_R, implies that the density of states in a microcanonical ensemble, at excitations Delta and Delta-bar and
A Maloney   +34 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Diagnostic performance of rapid antigen testing for SARS-CoV-2: the COVid-19 AntiGen (COVAG) extension study

open access: yesFrontiers in Medicine
BackgroundThis study is the extension of the COVAG study. We compared two RATs, the Panbio COVID-19 Ag Rapid Test (Abbott) and the SD Biosensor Q SARS-CoV-2 Rapid Antigen Test (Roche), against RT-PCR on the foil of new variants.MethodsWe included 888 all-
Christoph Wertenauer   +12 more
doaj   +1 more source

Shareny Bugor Fortified Settlement (the Town of Hajji Tarkhan) and its Neighbouring Area

open access: yesПоволжская археология, 2018
The author analyzes the new information on the localization of the Golden Horde town of Hajji Tarkhan (Shareny Bugor settlement) and its neighbouring area. The foundation period of the fortified settlement is proposed.
Pigarev Evgeniy M.
doaj   +1 more source

Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review

open access: yesHuman Vaccines & Immunotherapeutics, 2023
Despite widespread mass rollout programs, the rapid spread of the SARS-CoV-2 Omicron variant called into question the effectiveness of the existing vaccines against infection, hospitalization, severity, and mortality compared to previous variants.
Pradipta Paul   +26 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Predicting Dynamic Coastal Delta Change in Response to Sea-Level Rise

open access: yesJournal of Marine Science and Engineering, 2017
The world’s largest deltas are densely populated, of significant economic importance and among the most valuable coastal ecosystems. Projected twenty-first century sea-level rise (SLR) poses a threat to these low-lying coastal environments with ...
Wietse I. Van De Lageweg   +1 more
doaj   +1 more source

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