Results 71 to 80 of about 2,303,071 (294)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hydrobiological Investigation of Channels in the Mouth Region of the Lena River [PDF]
Учёные записки Казанского университета: Серия Естественные науки, 2015 The current taxonomic composition, structure, and quantitative characteristics of zooplankton in channels of the mouth region of the Lena River were considered.
G.R. Nigamatzyanova +3 more
doaj
Predominant variable region gene usage by gamma/delta T cell receptor-bearing cells in the adult thymus. [PDF]
, 1988 Previous studies have indicated that the diversity of gamma genes expressed by gamma/delta-bearing murine T cells is limited, but comparable information concerning the expressed diversity of delta genes is lacking. In this study, we have investigated the
Korman, A +4 more
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Teacher Vital Signs: A Two-Country Study of Teacher Vitality
, 2010 Defining teacher vitality as the vigor, energy, passion, and joy teachers bring to their classroom, students and colleagues; this article describes an international, comparative, qualitative, phenomenological study of teachers’ lived experiences to ...
Cavner, Delta, Ed.D.
core
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Continental Scale Mapping of Tidal Flats across East Asia Using the Landsat Archive
Remote Sensing, 2012 Tidal flats provide habitat for biodiversity, protection from storm surges and sea level rise, and a range of other ecosystem services. However, no simple method exists for mapping tidal flats over large (>1,000 km) extents, and ...
Richard A. Fuller +4 more
doaj +1 more source
c-axis transport and phenomenology of the pseudo-gap state in $Bi_2Sr_2CaCu_2O_{8+\delta}$
, 2004 We measure and analyze the resistivity of $Bi_2Sr_2CaCu_2O_{8+\delta}$ crystals for different doping $\delta$. We obtain the fraction of carrier $\eta(T,\delta) = n_g/n_{TOT}$ that do not participate to the c-axis conductivity.
A. G. Rojo +7 more
core +1 more source