Results 21 to 30 of about 1,441 (129)

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Nature Communications, 2021
Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.
Michal S. Barski, Teresa Vanzo, Xue Zhi Zhao, Steven J. Smith, Allison Ballandras-Colas, Nora B. Cronin, Valerie E. Pye, Stephen H. Hughes, Terrence R. Burke, Peter Cherepanov, Goedele N. Maertens   +10 more
doaj   +1 more source

Virus de la leucemia bovina: entre la producción animal y la salud humana

Revista Mvz Cordoba, 2023
El virus de la leucemia bovina (BLV) es un retrovirus del género deltaretrovirus, el cual infecta los linfocitos B y genera una expansión policlonal. En los rumiantes se integra como provirus al genoma del huésped y genera una infección de por vida.
Daniela Paternina B, Marco González T, Salim Mattar V   +2 more
doaj   +1 more source

Investigating Infectious Organisms of Public Health Concern Associated with Wild Meat

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
The wild meat trade poses a significant threat to public health as it facilitates the spillover of zoonotic pathogens through high‐risk activities such as the hunting, butchering, trade, and consumption of wild animals. Despite the health risks and association with marking epidemics including SARS, Ebola, and COVID‐19, the global wild meat trade ...
Georgia Kate Moloney, Philippe Gaubert, Sophie Gryseels, Erik Verheyen, Anne-Lise Chaber, Karima Al Salihi   +5 more
wiley   +1 more source

Diagnostic accuracy of Abbott Architect Assay as a screening tool for human T‐cell leukaemia virus type‐1 and type‐2 infection in a London teaching hospital with a large solid organ transplant centre

Transfusion Medicine, Volume 32, Issue 3, Page 256-260, June 2022., 2022
Abstract Aim In the United Kingdom, organ donors/recipients are screened for evidence of human T‐cell leukaemia virus type‐1 and type‐2 (HTLV‐1/2) infections. Since the United Kingdom is a low prevalence country for HTLV infections, a screening assay with high sensitivity and specificity is required.
Nathaniel Lee, Jamie Murphy, Rasheed Al‐Khudairi, Ann Sturdy, Tabitha Mahungu, Tanzina Haque, Paul Griffiths, Jennifer Tosswill, Dianne Irish   +8 more
wiley   +1 more source

Deltaretroviruses have circulated since at least the Paleogene and infected a broad range of mammalian species

Retrovirology, 2019
The Deltaretrovirus genus of retroviruses (family Retroviridae) includes the human T cell leukemia viruses and bovine leukemia virus (BLV). Relatively little is known about the biology and evolution of these viruses, because only a few species have been ...
Tomáš Hron, Daniel Elleder, Robert J. Gifford   +2 more
doaj   +1 more source

Prevalencia del virus de la leucosis bovina en búfalos de agua en la región centro occidental de Colombia

Revista Mexicana de Ciencias Pecuarias, 2021
La leucosis viral bovina (LVB) es una enfermedad de alta morbilidad y baja mortalidad. Existen reportes de la infección natural en algunas especies de bóvidos; sin embargo, en búfalos es poco estudiado.
Juan Carlos Rincón Flórez, Edgar Antonio Peláez Peláez, Nathaly Trejos Marín, Juan Carlos Echeverry López, Juan Carlos González Corrales   +4 more
doaj   +1 more source

The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases

Medicinal Research Reviews, Volume 42, Issue 2, Page 897-945, March 2022., 2022
Abstract Propolis is a complex natural product that possesses antioxidant, anti‐inflammatory, immunomodulatory, antibacterial, and antiviral properties mainly attributed to the high content in flavonoids, phenolic acids, and their derivatives. The chemical composition of propolis is multifarious, as it depends on the botanical sources from which ...
Andrea Magnavacca, Enrico Sangiovanni, Giorgio Racagni, Mario Dell'Agli   +3 more
wiley   +1 more source

Different Mutation Tolerance of Lentiviral (HIV-1) and Deltaretroviral (BLV and HTLV) Protease Precursors

Viruses, 2022
The bovine leukemia virus (BLV) and the human T-lymphothropic viruses (HTLVs) are members of the deltaretrovirus genus of Retroviridae family. An essential event of the retroviral life cycle is the processing of the polyproteins by the viral protease (PR)
János András Mótyán, Norbert Kassay, Krisztina Matúz, József Tőzsér   +3 more
doaj   +1 more source

A pooled testing system to rapidly identify cattle carrying the elite controller BoLA‐DRB3*009:02 haplotype against bovine leukemia virus infection

HLA, Volume 99, Issue 1, Page 12-24, January 2022., 2022
As genetically resistant individuals, the “elite controllers” (ECs) of human immunodeficiency virus infection have been focused on as the keys to developing further functional treatments in medicine. In the livestock production field, identifying the ECs of bovine leukemia virus (BLV) infection in cattle is desired to stop BLV transmission chains on ...
Kosuke Notsu, Hala El Daous, Shuya Mitoma, Junzo Norimine, Satoshi Sekiguchi   +4 more
wiley   +1 more source

First Evidence of Bovine Leukemia Virus in Culicoides Biting Midges and the Stable Fly Stomoxys calcitrans Collected on Cattle Farms in Poland. [PDF]

Transbound Emerg Dis
Bovine leukemia virus (BLV) is a cell‐associated retrovirus of cattle transmitted mainly through the transfer of infected lymphocytes, but the possible role of hematophagous insects in its epidemiology remains incompletely understood. This study investigated BLV DNA in field‐collected Culicoides biting midges and Stomoxys calcitrans from cattle farms ...
Pluta A, Kowalik J, Rożek W, Kwaśnik M, Ziętek-Barszcz A, Kuźmak J.   +5 more
europepmc   +2 more sources