Results 41 to 50 of about 1,388 (138)

Molecular Studies of HTLV-1 Replication: An Update

open access: yesViruses, 2016
Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers.
Jessica L. Martin   +4 more
doaj   +1 more source

Genetic Variability of Bovine Leukemia Virus: Evidence of Dual Infection, Recombination and Quasi-Species. [PDF]

open access: yesPathogens
We have characterized the intrahost genetic variation in the bovine leukemia virus (BLV) by examining 16 BLV isolates originating from the Western Siberia–Tyumen and South Ural–Chelyabinsk regions of Russia.
Pluta A   +5 more
europepmc   +2 more sources

New Insights into HTLV-1 Particle Structure, Assembly, and Gag-Gag Interactions in Living Cells

open access: yesViruses, 2011
Human T-cell leukemia virus type 1 (HTLV-1) has a reputation for being extremely difficult to study in cell culture. The challenges in propagating HTLV-1 has prevented a rigorous analysis of how these viruses replicate in cells, including the detailed ...
Jolene L. Johnson   +6 more
doaj   +1 more source

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

open access: yesNature Communications, 2020
Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
Michał S. Barski   +6 more
doaj   +1 more source

Distinct Morphology of Human T-Cell Leukemia Virus Type 1-Like Particles

open access: yesViruses, 2016
The Gag polyprotein is the main retroviral structural protein and is essential for the assembly and release of virus particles. In this study, we have analyzed the morphology and Gag stoichiometry of human T-cell leukemia virus type 1 (HTLV-1)-like ...
José O. Maldonado   +3 more
doaj   +1 more source

Molecular and Serological Evaluation of Bovine Leukemia Virus in Water Buffaloes of Southern Iran [PDF]

open access: yesIranian Journal of Veterinary Medicine, 2020
BACKGROUND: Bovine leukemia virus (BLV) is an oncogenic deltaretrovirus causing a persistent lifelong infection of B lymphocytes. In addition to the domestic cattle, the virus can also infect water buffaloes.
Atefeh Esmailnejad   +2 more
doaj   +1 more source

Exploring the presence of bovine leukemia virus among breast cancer tumors in a rural state

open access: yesBreast Cancer Research and Treatment, 2023
Purpose The bovine leukemia virus (BLV) is a deltaretrovirus that causes malignant lymphoma and lymphosarcomas in cattle globally and has high prevalence among large scale U.S. dairy herds. Associations between presence of BLV DNA in human mammary tissue
S. Amato   +8 more
semanticscholar   +1 more source

Upregulation of host genes during disease progression in bovine leukemia virus infection is independent of overexpression of viral transcriptional regulators in vitro

open access: yesArchives of Virology, 2023
Bovine leukemia virus (BLV) is a member of the genus Deltaretrovirus within the family Retroviridae that infects bovine B cells, causing persistent lymphocytosis and enzootic bovine leukosis (EBL) in a small fraction of infected cattle. As changes in the
A. Nishimori   +4 more
semanticscholar   +1 more source

No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms

open access: yesRetrovirology, 2007
Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic ...
Hoelzer Dieter   +4 more
doaj   +1 more source

Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV‐1 Perspective

open access: yesLeukemia Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Cell type specificity of human T cell leukemia virus 1 has been proposed as a possible reason for differential viral outcome in primary target cells versus secondary. Through chromatin remodeling, the HTLV‐1 transactivator protein Tax interacts with cellular factors at the chromosomally integrated viral promoter to activate downstream genes and control
Nishat Aliya   +4 more
wiley   +1 more source

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