Results 111 to 120 of about 2,863,040 (292)

SUPPLY RESPONSE, DEMAND AND STOCKS FOR SOUTHERN AFRICAN BEEF [PDF]

Livestock Production/Industries,
Kirsten, Johann F., van Renen, E., von Bach, Helmke J. Sartorius   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Demand Flexibility: A Review of Quantification Methods, Models, and Required Data

Applied Sciences
As renewable energy is increasingly integrated into our electricity supply, it becomes more challenging to ensure reliability and security due to the intermittent nature of these resources.
Morgan M. Shepherd, Salman Mohagheghi
doaj   +1 more source

Assessing the Competitive Interaction Between Private Labels and National Brands [PDF]

In contrast to single-equation cross-sectional studies of private label share, developing a complete understanding of the nature of the competitive interaction between national brands and private labels requires an understanding of the determinants of ...
Cotterill, Ronald W., Dhar, Ravi, Putsis, William P., Jr.   +2 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Demand Response Program Toward Sustainable Power Supply: Current Status, Challenges, and Prospects in Malaysia

IEEE Access
Rising carbon (CO2) emissions, driven by increasing energy demand across residential, commercial, and industrial sectors, present a critical environmental challenge, exacerbating climate change.
Mohammad Sameer Ahmad, Nurulafiqah Nadzirah Mansor, Hazlie Mokhlis, Kanendra Naidu, Hasmaini Mohamad, Farah Ramadhani   +5 more
doaj   +1 more source

The Response of Prices, Sales, and Output to Temporary Changes in Demand [PDF]

We determine empirically how the Big Three automakers accommodate shocks to demand. They have the capability to change prices, alter labor inputs through temporary layoffs and overtime, or adjust inventories.
Adam Copeland, George Hall
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source