Results 1 to 10 of about 1,288,443 (403)
Seminars in Neurology, 2016 Dementia often is defined as a progressive cognitive disturbance leading to a loss of independent function. Most clinicians are familiar with the typical pattern of amnestic Alzheimer's disease, the most common neurodegenerative presentation of dementia.
Ljubenkov, Peter A, Geschwind, Michael D
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BMC Medical Informatics and Decision Making, 2021 Background Data sparsity is a major limitation to estimating national and global dementia burden. Surveys with full diagnostic evaluations of dementia prevalence are prohibitively resource-intensive in many settings.
GBD 2019 Dementia Collaborators
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Biology, 2023 Global cerebral ischemia can elicit rapid innate neuroprotective mechanisms that protect against delayed neuronal death. Brain-derived 17β-estradiol (BDE2), an endogenous neuroprotectant, is synthesized from testosterone by the enzyme aromatase (Aro) and
Jing Xu +7 more
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BMC Geriatrics, 2021 Background Hearing and vision loss in older people has been proven to affect physical and mental health and increase the speed of cognitive decline. Studies have demonstrated that certain practices and improved staff knowledge increase the effective care
Wendy Andrusjak +2 more
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Alzheimer’s Research & Therapy, 2020 Background There is increasing interest in improving understanding of the timing and nature of early neurodegeneration in Alzheimer’s disease (AD) and developing methods to measure this in vivo.
Philip S. J. Weston +12 more
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Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?
EMBO Molecular Medicine, 2021 On 7 June, the FDA approved aducanumab, the first new drug for Alzheimer’s disease in almost 20 years—and notably, the first drug with a putative disease‐modifying mechanism for the treatment of this devastating disorder, namely the removal of β‐amyloid (
Giovanna Lalli +3 more
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BMC Public Health, 2023 Background Unmanaged cardiometabolic health, low physical and cognitive activity, poor diet, obesity, smoking and excessive alcohol consumption are modifiable health risk factors for dementia and public health approaches to dementia prevention have been ...
Larissa Bartlett +9 more
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PAIN Reports, 2020 AbstractThe ageing revolution is changing the composition of our society with more people becoming very old with higher risks for developing both pain and dementia. Pain is normally signaled by verbal communication, which becomes more and more deteriorated in people with dementia.
Achterberg, Wilco +4 more
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Practical Neurology, 2003 Vascular dementia is one of the most frequently occurring dementia syndromes. Its prevalence is about 5% among subjects above 85 years of age. Elevated blood pressure and atherosclerosis are the most important risk factors. According to international criteria, vascular dementia usually occurs within three months after having a stroke.
Leeuw, H.F. de, Gijn, J. van
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Investigation of early molecular alterations in tauopathy with generative adversarial networks
Scientific Reports, 2023 The recent advances in deep learning-based approaches hold great promise for unravelling biological mechanisms, discovering biomarkers, and predicting gene function.
Hyerin Kim +4 more
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