Results 1 to 10 of about 1,135,748 (429)
Biology, 2023 Global cerebral ischemia can elicit rapid innate neuroprotective mechanisms that protect against delayed neuronal death. Brain-derived 17β-estradiol (BDE2), an endogenous neuroprotectant, is synthesized from testosterone by the enzyme aromatase (Aro) and
Jing Xu +7 more
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BMC Medical Informatics and Decision Making, 2021 Background Data sparsity is a major limitation to estimating national and global dementia burden. Surveys with full diagnostic evaluations of dementia prevalence are prohibitively resource-intensive in many settings.
GBD 2019 Dementia Collaborators
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BMC Geriatrics, 2021 Background Hearing and vision loss in older people has been proven to affect physical and mental health and increase the speed of cognitive decline. Studies have demonstrated that certain practices and improved staff knowledge increase the effective care
Wendy Andrusjak +2 more
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Automated Analysis of Drawing Process for Detecting Prodromal and Clinical Dementia [PDF]
2022 IEEE International Conference on Digital Health (ICDH), 2022 Early diagnosis of dementia, particularly in the prodromal stage (i.e., mild cognitive impairment, or MCI), has become a research and clinical priority but remains challenging. Automated analysis of the drawing process has been studied as a promising means for screening prodromal and clinical dementia, providing multifaceted information encompassing ...
arxiv +1 more source
The worldwide costs of dementia in 2019
Alzheimer's & Dementia, 2023 Dementia is a leading cause of death and disability globally. Estimating total societal costs demonstrates the wide impact of dementia and its main direct and indirect economic components.
A. Wimo +13 more
semanticscholar +1 more source
Alzheimer’s Research & Therapy, 2020 Background There is increasing interest in improving understanding of the timing and nature of early neurodegeneration in Alzheimer’s disease (AD) and developing methods to measure this in vivo.
Philip S. J. Weston +12 more
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BMC Public Health, 2023 Background Unmanaged cardiometabolic health, low physical and cognitive activity, poor diet, obesity, smoking and excessive alcohol consumption are modifiable health risk factors for dementia and public health approaches to dementia prevention have been ...
Larissa Bartlett +9 more
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BMC Health Services Research, 2021 Background Dementia Care Mapping™ (DCM) is a widely used, staff-led, psychosocial intervention to support the implementation of person-centred care. Efficacy evaluations in care homes have produced mixed outcomes, with implementation problems identified.
Alys Wyn Griffiths +4 more
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Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?
EMBO Molecular Medicine, 2021 On 7 June, the FDA approved aducanumab, the first new drug for Alzheimer’s disease in almost 20 years—and notably, the first drug with a putative disease‐modifying mechanism for the treatment of this devastating disorder, namely the removal of β‐amyloid (
Giovanna Lalli +3 more
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