Results 111 to 120 of about 262,612 (300)

Dementia due to cerebral small vessel damage: Current ideas on its pathogenesis and therapy

Неврология, нейропсихиатрия, психосоматика, 2014
Ever-increasing attention now focusses on dementia caused by small vessel damage when considering cerebrovascular disease leading to cognitive impairments (CIs).
I. V. Damulin, E. V. Ekusheva
doaj   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Characteristics and overall survival in patients with T1 melanoma: A nationwide matched cohort study

International Journal of Cancer, EarlyView.
What's New? Thin cutaneous malignant melanoma has an excellent ten‐year melanoma‐specific survival of 93%–97%. Moreover, the incidence of melanoma is higher among individuals with high socioeconomic status, which may protect them from other diseases. This nationwide matched cohort study found that patients with thin cutaneous malignant melanoma have a ...
Ylva Naeser, Rasmus Mikiver, Karolin Isaksson, Mats Lambe, Gustav J. Ullenhag   +4 more
wiley   +1 more source

Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and Management

Biomolecules
Vascular dysfunction frequently coexists with neurodegenerative disorders such as dementia and Alzheimer’s disease (AD) in older individuals; however, the cause-and-effect relationship remains unclear. While AD is primarily characterized by neural tissue
Avanthika Mekala, Hongyu Qiu
doaj   +1 more source

Biomarkers and Risk Factors of Dementia [PDF]

, 2011
Dementia is a devastating disease that is common in elderly people. The prevalence increases from almost 1% at age 65 to over 40% of people older than 90 years.1 Because the population is aging, the number of people living with dementia world- wide is ...
Schrijvers, E.M.C. (Elisabeth M. C.)
core  

Causal effects of reproductive traits on cognitive function: A two‐sample and multivariable mendelian randomization study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Potential associations between reproductive traits and cognitive function have been discovered; however, the results are inconsistent, and the causalities are unclear. This study utilized Mendelian randomization (MR) analysis to assess the causal impact of reproductive traits on cognitive function.
Xia Wang, Yunyun Guo
wiley   +1 more source

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Neuropsychiatric symptoms in Vascular Cognitive Impairment: A systematic review

Dementia & Neuropsychologia
Neuropsychiatric symptoms or Behavioral and Psychological Symptoms of Dementia (BPSD) are common and invariably appear at some point during the course of the disease, mediated both by cerebrovascular disease and neurodegenerative processes.
Chan Tiel, Felipe Kenji Sudo, Gilberto Sousa Alves, Letice Ericeira-Valente, Denise Madeira Moreira, Jerson Laks, Eliasz Engelhardt   +6 more
doaj   +1 more source

Lymph‐based liquid biopsy: Current progress and future potential

Interdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo   +6 more
wiley   +1 more source