Results 91 to 100 of about 266,371 (307)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Updating data on cognitive impairment in stroke patients

Journal of Mind and Medical Sciences
Vascular cognitive impairments are the expression of complex interactions between vascular etiology, risk factors (brain diseases, white matter lesions, etc.) and cellular changes at the brain level.
Denisa Floriana Vasilica Pîrșcoveanu, Carmen Valeria Albu, Elena Anca Târtea, Iulia Cristina Mărginean, George Alexandru Iacob, Elena Pinoșanu, Anca Maria Țucă, Cristina Maria Mărginean, Raluca Elena Sandu, Mircea Pîrșcoveanu   +9 more
doaj   +1 more source

The association of vascular disorders with incident dementia in different age groups

Alzheimer’s Research & Therapy, 2019
Background There is increasing evidence that dementia risk associated with vascular disorders is age dependent. Large population-based studies of incident dementia are necessary to further elucidate this effect.
Nienke Legdeur, Sven J. van der Lee, Marcel de Wilde, Johan van der Lei, Majon Muller, Andrea B. Maier, Pieter Jelle Visser   +6 more
doaj   +1 more source

Hemostasis biomarkers and incident cognitive impairment: the REGARDS study [PDF]

, 2018
Essentials Cognitive disorders are increasing and vascular risk factors play a role in this. We performed a nested case control study of hemostasis biomarkers and cognitive impairment (CI). Higher baseline fibrinogen, factor VIII and D-dimer were related
Callas, P.W., Cushman, M., Gillett, S.R., Letter, A.J., McClure, L.A., Thacker, E.L., Unverzagt, F.W., Wadley, V.G.   +7 more
core   +1 more source

Updates in Vascular Dementia

Heart and Mind, 2017
It has been more than a hundred years since Alzheimer and Binswanger's first description of vascular dementia (VaD). Ever since then, histopathology research and neuroimaging techniques have allowed the development of new pathogenic, etiologic, and treatment hypotheses.
Nora Olazabal Eizaguirre, Gerardo Priego Rementeria, Miguel Ángel González-Torres, Moises Gaviria   +3 more
openaire   +2 more sources

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

Risk of dementia following retinal vascular occlusions: A propensity-score matched cohort study using a global federated database

Journal of Stroke and Cerebrovascular Diseases
Objective: : Retinal vascular occlusions (RVaO), including retinal artery occlusion (RAO) and retinal vein occlusion (RVO), are common retinal vascular disorders that may indicate systemic vascular disease and cerebral microvascular pathology. This study
Cheng-Yang Hsieh, MD, PhD, Sheng-Feng Sung, MD, PhD   +1 more
doaj   +1 more source

Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans [PDF]

, 2019
Although the association between high blood pressure (BP), particularly in midlife, and late-life dementia is known, less is known about variations by race and sex.
Cushman, Mary, Galecki, Andrzej T., Giordani, Bruno, Kabeto, Mohammed U., Langa, Kenneth M., Levine, Deborah A., McClure, Leslie A., Safford, Monika M., Unverzagt, Frederick W., Wadley, Virginia G.   +9 more
core   +1 more source