Research progress on biomarkers of traumatic brain injury
Animal Models and Experimental Medicine, EarlyView.Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen +8 more
wiley +1 more source
Clinical efficacy of long-term treatment in patients with vascular dementia
Бюллетень сибирской медицины, 2011 To study efficacy and safety of prolonged course of cerebrolysin therapy in vascular dementia, 48 patients, aged from 59—77 years, with mild and moderate dementia have been studied.
I. A. Suvorova
doaj +1 more source
Relationship between antihypertensive medications and cognitive impairment: Part I. review of human studies and clinical trials [PDF]
, 2016 Purpose of review: There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHMs) and dementia risk ...
Anstey, KJ +5 more
core +2 more sources
Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies
Animal Models and Experimental Medicine, EarlyView.This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang +4 more
wiley +1 more source
The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia
Neural Regeneration ResearchWith an increase in global aging, the number of people affected by cerebrovascular diseases is also increasing, and the incidence of vascular dementia—closely related to cerebrovascular risk—is increasing at an epidemic rate.
Xiaorong Zhang +5 more
doaj +1 more source
Late-life depression : issues for the general practitioner [PDF]
, 2018 Late-life depression (LLD) is both a prevalent and life-threatening disorder, affecting up to 13.3% of the elderly population. LLD can be difficult to identify because patients mainly consult their general practitioner (GP) for somatic complaints ...
Declercq, Tom +4 more
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Alzheimer's Disease Co‐Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis
Annals of Neurology, EarlyView.Objectives Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) share neuropathological features, including tau, amyloid, and TDP‐43 pathology. This study investigated whether AD‐related pathological changes are associated with cognitive impairment ALS. Methods Cerebrospinal fluid (CSF total‐tau, phosphorylated‐tau, beta‐amyloid) and plasma
Elisabeth Kasper +29 more
wiley +1 more source
Dementia due to cerebral small vessel damage: Current ideas on its pathogenesis and therapy
Неврология, нейропсихиатрия, психосоматика, 2014 Ever-increasing attention now focusses on dementia caused by small vessel damage when considering cerebrovascular disease leading to cognitive impairments (CIs).
I. V. Damulin, E. V. Ekusheva
doaj +1 more source
Prevalence and pattern of cognitive impairment in rural and urban populations from Northern Portugal [PDF]
, 2010 Background Despite worldwide recognition of the burden of dementia, no epidemiological data is yet available in Portugal. The objective of this study is to estimate the prevalence and describe the pattern of cognitive impairment with dementia or no ...
Belina Nunes +5 more
core +2 more sources
Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers
Annals of Neurology, EarlyView.Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang +45 more
wiley +1 more source