Results 171 to 180 of about 262,612 (300)

Vessel‐associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease

Brain Pathology, EarlyView.
This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner, Robert A. Fisher, Daniel J. Asby, Stephen Cross, Delphine Boche, J. Scott Miners   +5 more
wiley   +1 more source

Temporal comorbidity patterns in Alzheimer's disease and vascular dementia: A population-based observational study in UK Biobank. [PDF]

Alzheimers Dement (Amst)
Walsh C, Fogel A, Schalkamp AK, Mabiala V, Shariati B, Sandor C, Ryten M, Nilforooshan R, Barnaghi P.   +8 more
europepmc   +1 more source

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, EarlyView.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

Oxidative Stress as a Central Mechanistic Bridge Between Alzheimer's and Vascular Pathologies in Mixed Dementia: Emerging Evidence and Therapeutic Perspectives. [PDF]

Biomedicines
Beretti F, Malenchini M, Gatti M, Maraldi T.   +3 more
europepmc   +1 more source

Risk Factors for Dementia and Cognitive Decline [PDF]

, 2003
Gilhooly, M, Gow, J
core  

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

Brain Pathology, EarlyView.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis, Lauren A. Ignatz, Sathish Selvam, Marc C. E. Wagner, Sara Gianella, Antoine Chaillon, Vanessa Gomez‐Moreno, Jeremy Martison, Leah H. Rubin, Sabina Heberlen, Valentina Stosor, Jordan Lake, Velpandi Ayyavoo   +12 more
wiley   +1 more source

Corrigendum: Evaluation of Metformin on Cognitive Improvement in Patients With Non-dementia Vascular Cognitive Impairment and Abnormal Glucose Metabolism. [PDF]

Front Aging Neurosci, 2018
Lin Y, Wang K, Ma C, Wang X, Gong Z, Zhang R, Zang D, Cheng Y.   +7 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Sex differences in the association of vascular risk and APOE Genotype with cognitive decline and dementia: evidence from a U.S. longitudinal study. [PDF]

Lancet Reg Health Am
Liu L, Hou J, Cui S, Zhao X, Liu Z, Longenecker JC, May NS, Luo JJ, DiMaria-Ghalili RA, Eisen HJ.   +9 more
europepmc   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source