A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing
Advanced Science, EarlyView.This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang +17 more
wiley +1 more source
Advanced Science, EarlyView.FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou +8 more
wiley +1 more source
FATTY DEGENERATION OF THE CEREBRAL CORTEX IN THE PSYCHOSES, WITH SPECIAL REFERENCE TO DEMENTIA PRÆCOX [PDF]
, 1915 Henry A. Cotton
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Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
Advanced Science, EarlyView.LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao +9 more
wiley +1 more source
A COMPARISON OF PERSONAL CHARACTERISTICS IN DEMENTIA PRÆCOX AND MANIC-DEPRESSIVE PSYCHOSIS [PDF]
, 1912 EARL D. BOND, E. Stanley Abbot
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Traumatic injury and dementia in New Zealand : a Palmerston North Hospital case-control study : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Health Science in Psychology at Massey University, Palmerston North, New Zealand [PDF]
, 2015 Little is known about the relationship between traumatic injury (TI) and dementia. The increasing prevalence of both conditions in the world and in New Zealand (NZ) drove the Author to want to investigate whether the pathophysiological consequences of ...
Westerberg, Virginia
core
Advanced Science, EarlyView.Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high‐resolution imaging approaches, a variety of canonical and undescribed fibril morphologies are identified.
Fabio Strati +8 more
wiley +1 more source
People Living With Dementia and Their Families as Educators for Social Justice
Health ExpectationsBackground It is increasingly recognised that dementia education and training should include the direct voices of Experts by Experience (people living with dementia and their families).
Clare Mason +4 more
doaj +1 more source
Kritischer beitrag zu der serologie der dementia praecox [PDF]
, 1922 Hans Roemer
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