Results 11 to 20 of about 579,799 (311)

Dementia [PDF]

open access: yesNursing Standard, 2016
'The dementia case-finding tool can be used by care workers to identify care home residents who may have dementia. Used before a clinician's visit, it means their time is more focused'.
Ljubenkov, Peter A, Geschwind, Michael D
  +9 more sources

Use of multidimensional item response theory methods for dementia prevalence prediction: an example using the Health and Retirement Survey and the Aging, Demographics, and Memory Study

open access: yesBMC Medical Informatics and Decision Making, 2021
Background Data sparsity is a major limitation to estimating national and global dementia burden. Surveys with full diagnostic evaluations of dementia prevalence are prohibitively resource-intensive in many settings.
GBD 2019 Dementia Collaborators
doaj   +1 more source

Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats

open access: yesBiology, 2023
Global cerebral ischemia can elicit rapid innate neuroprotective mechanisms that protect against delayed neuronal death. Brain-derived 17β-estradiol (BDE2), an endogenous neuroprotectant, is synthesized from testosterone by the enzyme aromatase (Aro) and
Jing Xu   +7 more
doaj   +1 more source

Hearing and vision care provided to older people residing in care homes: a cross-sectional survey of care home staff

open access: yesBMC Geriatrics, 2021
Background Hearing and vision loss in older people has been proven to affect physical and mental health and increase the speed of cognitive decline. Studies have demonstrated that certain practices and improved staff knowledge increase the effective care
Wendy Andrusjak   +2 more
doaj   +1 more source

Measuring cortical mean diffusivity to assess early microstructural cortical change in presymptomatic familial Alzheimer’s disease

open access: yesAlzheimer’s Research & Therapy, 2020
Background There is increasing interest in improving understanding of the timing and nature of early neurodegeneration in Alzheimer’s disease (AD) and developing methods to measure this in vivo.
Philip S. J. Weston   +12 more
doaj   +1 more source

An online, public health framework supporting behaviour change to reduce dementia risk: interim results from the ISLAND study linking ageing and neurodegenerative disease

open access: yesBMC Public Health, 2023
Background Unmanaged cardiometabolic health, low physical and cognitive activity, poor diet, obesity, smoking and excessive alcohol consumption are modifiable health risk factors for dementia and public health approaches to dementia prevention have been ...
Larissa Bartlett   +9 more
doaj   +1 more source

Staff experiences of implementing Dementia Care Mapping to improve the quality of dementia care in care homes: a qualitative process evaluation

open access: yesBMC Health Services Research, 2021
Background Dementia Care Mapping™ (DCM) is a widely used, staff-led, psychosocial intervention to support the implementation of person-centred care. Efficacy evaluations in care homes have produced mixed outcomes, with implementation problems identified.
Alys Wyn Griffiths   +4 more
doaj   +1 more source

A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer's Disease: DONIPAD study

open access: yesAlzheimer’s Research & Therapy, 2018
Background The study investigated whether donepezil exerts symptomatic benefit in patients with posterior cortical atrophy (PCA), an atypical variant of Alzheimer’s disease.
Basil H. Ridha   +10 more
doaj   +1 more source

Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?

open access: yesEMBO Molecular Medicine, 2021
On 7 June, the FDA approved aducanumab, the first new drug for Alzheimer’s disease in almost 20 years—and notably, the first drug with a putative disease‐modifying mechanism for the treatment of this devastating disorder, namely the removal of β‐amyloid (
Giovanna Lalli   +3 more
doaj   +1 more source

Investigation of early molecular alterations in tauopathy with generative adversarial networks

open access: yesScientific Reports, 2023
The recent advances in deep learning-based approaches hold great promise for unravelling biological mechanisms, discovering biomarkers, and predicting gene function.
Hyerin Kim   +4 more
doaj   +1 more source

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