Results 191 to 200 of about 940,684 (303)

Two‐Nanosensor Electrochemical Profiling of Catecholamine Vesicle Interactions With Acute and Chronic Stress Granules in Living Cells

Angewandte Chemie, EarlyView.
A two‐nanosensor electrochemical strategy quantitatively distinguishes reactive oxygen species (ROS) in stress granules (SGs) from catecholamines in vesicles inside living cells. Chronic SGs formed under prolonged stress show elevated ROS and slower release, consistent with SG aging, and promote neurotransmitter loading likely through vesicle fusion ...
Hui Gu, Chaoyi Gu, Andre Du Toit, Andrew G. Ewing   +3 more
wiley   +2 more sources

The use of immersive virtual reality technology in dementia care education for nursing students: A scoping review protocol. [PDF]

PLoS One
Wong JOY, Hung L, Phinney A, Sun W.
europepmc   +1 more source

Distinct Prescription Patterns Emerge Years Before ALS Diagnosis: A Nationwide Registry‐Based Study

Annals of Neurology, EarlyView.
Objective The prodromal phase of amyotrophic lateral sclerosis (ALS) is poorly defined. We aimed to characterize prescription drug use patterns in the pre‐diagnostic period by analyzing nationwide prescription data to identify the earliest divergence between individuals who developed ALS and matched healthy controls.
Magne Haugland Solheim, Trond Riise, Marianna Cortese, Ola Nakken, Ole‐Bjørn Tysnes, Jannicke Igland, Kjetil Bjornevik   +6 more
wiley   +1 more source

Access to healthcare services and adherence to treatments for people with dementia among ethnic minority groups: a scoping review. [PDF]

Front Dement
Aguzzoli E, Walbaum M, Knapp M.
europepmc   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, EarlyView.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study. [PDF]

Alzheimers Dement
Stafford J, Dekhtyar S, Russ TC, Singh-Manoux A, Maddock J, Walters K, Orgeta V, Davies N, Kirkbride JB, Richards M, Howard R, Patalay P.   +11 more
europepmc   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

Risk of Dementia in Patients With Type 2 Diabetes Using SGLT2 Inhibitors Versus DPP-4 Inhibitors: A Systematic Review and Meta-Analysis. [PDF]

Endocrinol Diabetes Metab
Kumari K, Bai A, Geeta F, Wadhwani N, Kumar R, Kumar A, Kumari R, Bai L, Muskan F, Kashish F, Yousafzai M.   +10 more
europepmc   +1 more source

Neuropsychiatric symptoms in preclinical and clinically manifest dementia: clusters and their health determinants. [PDF]

Alzheimers Dement
Guazzarini AG, Galaris E, Boccardi V, Mancinetti F, Ruggiero C, Muehlboeck JS, Mecocci P, Westman E, Marseglia A.   +8 more
europepmc   +1 more source

The sex-specific association between long-term PM2.5 exposure and incident dementia in community-dwelling older adults in Australia. [PDF]

Alzheimers Dement
Zhou A, Zhou Z, Yu W, Ye T, Owen A, Woods R, Orchard S, Wolfe R, Guo Y, Ryan J.   +9 more
europepmc   +1 more source