Results 21 to 30 of about 1,302,226 (351)

Treatment with glucagon‐like peptide‐1 receptor agonists and incidence of dementia: Data from pooled double‐blind randomized controlled trials and nationwide disease and prescription registers

Alzheimer's & Dementia, 2022
People with type 2 diabetes have increased risk of dementia. Glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are among the promising therapies for repurposing as a treatment for Alzheimer's disease; a key unanswered question is whether they ...
C. H. Nørgaard, Sarah Friedrich, C. T. Hansen, T. Gerds, C. Ballard, D. Møller, L. Knudsen, K. Kvist, B. Zinman, E. Holm, C. Torp‐Pedersen, Lina Steinrud Mørch   +11 more
semanticscholar   +1 more source

A roadmap to develop dementia research capacity and capability in Pakistan: a model for low- and middle-income countries [PDF]

, 2019
Objective To produce a strategic roadmap for supporting the development of dementia research in Pakistan. Background While global research strategies for dementia research already exist, none is tailored to the specific needs and challenges of low ...
Abbasi, Y., Chaudhry, N., Daniel, A., Dunne, R., Eitesam, S., Eman, S., Farina, N., Haidry, S., Husain, N., Jafri, H., Jafri, M., Karim, R., Karim, S., Khaliq, A., Khan, M., Khan, Q., Kiran, T., Leroi, I., Malik, S.J., Memon, R., Nafis, S., Rana, M.H., Sathish, A., Sheikh, S., Tamizudin, A., Tofique, S., Wasay, M., Zadeh, Z.   +27 more
core   +1 more source

Factors associated with successful dementia education for practitioners in primary care: an in-depth case study

BMC Medical Education, 2019
Background With increasing numbers of people in the UK living with dementia, the provision of good quality person-centred care that meets the often complex needs of this population is required.
Cara Sass, Natasha Burnley, Michelle Drury, Jan Oyebode, Claire Surr   +4 more
doaj   +1 more source

Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. [PDF]

, 2010
INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia. METHODS: A population-based sample of 856 individuals aged
Fisher, Gwenith G, Kabeto, Mohammed U, Lang, Iain A, Langa, Kenneth M, Llewellyn, David J, Matthews, Fiona E, Morgenstern, Lewis B, Plassman, Brenda L, Rogers, Mary A   +8 more
core   +5 more sources

Drawn from life: Cocreating narrative and graphic vignettes of lived experience with people affected by dementia

Health Expectations, 2021
Background The growing literature on Patient and Public Involvement and Engagement (PPIE) and dementia identifies specific problems related to the influence that involvement has on research outcomes, over‐reliance on family members as proxies and lack of
Andrea Capstick, Alison Dennison, Jan Oyebode, Lesley Healy, Claire Surr, Sahdia Parveen, Cara Sass, Michelle Drury   +7 more
doaj   +1 more source

Physiological phenotyping of dementias using emotional sounds

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Emotional behavioral disturbances are hallmarks of many dementias but their pathophysiology is poorly understood. Here we addressed this issue using the paradigm of emotionally salient sounds.
Phillip D. Fletcher, Jennifer M. Nicholas, Timothy J. Shakespeare, Laura E. Downey, Hannah L. Golden, Jennifer L. Agustus, Camilla N. Clark, Catherine J. Mummery, Jonathan M. Schott, Sebastian J. Crutch, Jason D. Warren   +10 more
doaj   +1 more source

Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

BMC Psychiatry, 2023
Background The Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia such as cognitive tests. Our aims were twofold: a) to describe a
Donncha S. Mullin, Lucy E. Stirland, Emily Buchanan, Catherine-Anne Convery, Simon R. Cox, Ian J. Deary, Cinzia Giuntoli, Holly Greer, Danielle Page, Elizabeth Robertson, Susan D. Shenkin, Anna Szalek, Adele Taylor, Georgina Weatherdon, Tim Wilkinson, Tom C. Russ   +15 more
doaj   +1 more source

Socioeconomic status as a risk factor for dementia death:individual participant meta-analysis of 86 508 men and women from the UK [PDF]

, 2013
Background Life-course socioeconomic factors may have a role in dementia aetiology but there is a current paucity of studies. Meta-analyses of individual participant data would considerably strengthen this evidence base.
Cox, Emmanuel Stamatakis, Ferri, G. David Batty, John M. Starr, Mark Hamer, Marmot, Mika Kivimäki, MRC, Norton, Snowdon, Tom C. Russ, von Elm   +12 more
core   +1 more source

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies

Experimental and Molecular Medicine, 2020
Neurodegenerative disorders: Spread of misfolded protein aggregates Further research is needed to determine how an aggregate-forming protein common to several neurodegenerative disorders propagates throughout the brain.
Myungjin Jo, Shinrye Lee, Yu-Mi Jeon, Seyeon Kim, Younghwi Kwon, Hyung-Jun Kim   +5 more
doaj   +1 more source

Activation of NMDA receptors in brain endothelial cells increases transcellular permeability

Fluids and Barriers of the CNS, 2022
Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose.
Kyu-Sung Kim, Min Tae Jeon, Eun Seon Kim, Chan Hee Lee, Do-Geun Kim   +4 more
doaj   +1 more source