Results 21 to 30 of about 579,799 (311)
Thalamic white matter macrostructure and subnuclei volumes in Parkinson’s disease depression
npj Parkinson's Disease, 2022 Depression is a common non-motor feature of Parkinson’s disease (PD) which confers significant morbidity and is challenging to treat. The thalamus is a key component in the basal ganglia-thalamocortical network critical to the pathogenesis of PD and ...
R. Bhome +5 more
doaj +1 more source
BMC Medical Education, 2019 Background With increasing numbers of people in the UK living with dementia, the provision of good quality person-centred care that meets the often complex needs of this population is required.
Cara Sass +4 more
doaj +1 more source
Physiological phenotyping of dementias using emotional sounds
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015 Introduction Emotional behavioral disturbances are hallmarks of many dementias but their pathophysiology is poorly understood. Here we addressed this issue using the paradigm of emotionally salient sounds.
Phillip D. Fletcher +10 more
doaj +1 more source
Experimental and Molecular Medicine, 2020 Neurodegenerative disorders: Spread of misfolded protein aggregates Further research is needed to determine how an aggregate-forming protein common to several neurodegenerative disorders propagates throughout the brain.
Myungjin Jo +5 more
doaj +1 more source
Health Expectations, 2021 Background The growing literature on Patient and Public Involvement and Engagement (PPIE) and dementia identifies specific problems related to the influence that involvement has on research outcomes, over‐reliance on family members as proxies and lack of
Andrea Capstick +7 more
doaj +1 more source
Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
Fluids and Barriers of the CNS, 2022 Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose.
Kyu-Sung Kim +4 more
doaj +1 more source
BMC Psychiatry, 2023 Background The Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia such as cognitive tests. Our aims were twofold: a) to describe a
Donncha S. Mullin +15 more
doaj +1 more source
Dementias show differential physiological responses to salient sounds
Frontiers in Behavioral Neuroscience, 2015 Abnormal responsiveness to salient sensory signals is often a prominent feature of dementia diseases, particularly the frontotemporal lobar degenerations, but has been little studied. Here we assessed processing of one important class of salient signals,
Phillip David Fletcher +10 more
doaj +1 more source
BMJ Open, 2021 Objectives The aim of this study was to establish the impact of dementia education and training on the knowledge, attitudes and confidence of health and social care staff.
Sahdia Parveen +6 more
doaj +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Containment measures implemented to minimize the spread of coronavirus disease 2019 (COVID‐19) are reported to be negatively affecting mental health, diet, and alcohol consumption.
Larissa Bartlett +7 more
doaj +1 more source