Results 41 to 50 of about 1,350,087 (353)

Change in modifiable dementia risk factors during COVID‐19 lockdown: The experience of over 50s in Tasmania, Australia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Containment measures implemented to minimize the spread of coronavirus disease 2019 (COVID‐19) are reported to be negatively affecting mental health, diet, and alcohol consumption.
Larissa Bartlett, James J. R. Brady, Maree Farrow, Sarang Kim, Aidan Bindoff, Hannah Fair, James C. Vickers, Duncan Sinclair   +7 more
doaj   +1 more source

Reframing dementia care in Maltese Hospitals [PDF]

, 2016
This commentary addresses the urgent need to improve the care of patients with dementia and cognitive impairment in Maltese hospitals by proposing a number of dementia-friendly hospital-based initiatives.
Scerri, Anthony, Scerri, Charles
core   +1 more source

Challenges and Lifelines: What Was Important to Family Carers of People With Dementia Accessing the Admiral Nurse Services, a Specialist Family-Centered Dementia Support?

SAGE Open, 2019
Admiral Nurses (ANs), specialists in dementia, provide care management to families affected by dementia. A survey was designed to explore family carers’ views on the care received.
Laura Maio, Julia Botsford, Karen Harrison Dening, Steve Iliffe   +3 more
doaj   +1 more source

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Nature Communications, 2021
While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price   +7 more
doaj   +1 more source

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Nature Communications, 2020
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes have a ...
E. Reiman, Joseph F. Arboleda-Velasquez, Y. Quiroz, M. Huentelman, T. Beach, R. Caselli, Yinghua Chen, Yi Su, A. Myers, J. Hardy, Jean Paul Vonsattel, S. Younkin, D. Bennett, P. D. De Jager, E. Larson, P. Crane, C. Keene, M. Kamboh, J. Kofler, Linda Duque, J. Gilbert, H. Gwirtsman, J. Buxbaum, D. Dickson, M. Frosch, B. Ghetti, K. Lunetta, Li-San Wang, B. Hyman, W. Kukull, T. Foroud, J. Haines, R. Mayeux, M. Pericak-Vance, J. Schneider, J. Trojanowski, L. Farrer, G. Schellenberg, G. Beecham, T. Montine, G. Jun, Erin Perrie M. Marilyn S. Roger L. Liana G. Steven E. S Abner Adams Albert Albin Apostolova Arnold Asthana, E. Abner, P. Adams, M. Albert, R. Albin, L. Apostolova, S. Arnold, S. Asthana, C. Atwood, C. Baldwin, R. Barber, L. Barnes, S. Barral, J. Becker, D. Beekly, E. Bigio, T. Bird, D. Blacker, B. Boeve, J. Bowen, A. Boxer, J. Burke, J. Burns, N. Cairns, L. Cantwell, C. Cao, C. Carlson, C. Carlsson, R. Carney, M. Carrasquillo, H. Chui, D. Cribbs, E. Crocco, C. Cruchaga, C. DeCarli, M. Dick, R. Doody, R. Duara, N. Ertekin-Taner, Denis A. Evans, K. Faber, T. Fairchild, K. Fallon, D. Fardo, M. Farlow, S. Ferris, D. Galasko, M. Gearing, D. Geschwind, Valentina Ghisays, A. Goate, N. Graff-Radford, R. C. Green, J. Growdon, H. Hakonarson, R. Hamilton, K. Hamilton-Nelson, L. Harrell, L. Honig, R. Huebinger, C. Hulette, G. Jarvik, Lee‐way Jin, A. Karydas, M. Katz, J. Kauwe, J. Kaye, Ronald C. Kim, N. Kowall, J. Kramer, B. Kunkle, Amanda P. Kuzma, F. LaFerla, J. Lah, Y. Leung, J. Leverenz, A. Levey, Ge Li, A. Lieberman, R. Lipton, O. Lopez, C. Lyketsos, J. Malamon, D. Marson, E. Martin, F. Martiniuk, D. Mash, E. Masliah, W. McCormick, S. McCurry, A. McDavid, S. McDonough, A. Mckee, M. Mesulam, B. Miller, C. Miller, Joshua W. Miller, J. Morris, S. Mukherjee, A. Naj, S. O'Bryant, J. Olichney, J. Parisi, Hank Paulson, E. Peskind, Ronald Petersen, A. Pierce, W. Poon, H. Potter, L. Qu, J. Quinn, A. Raj, Murray M. Raskind, B. Reisberg, J. Reisch, C. Reitz, J. Ringman, E. Roberson, E. Rogaeva, H. Rosen, R. Rosenberg, D. Royall, M. Sager, M. Sano, A. Saykin, L. Schneider, W. Seeley, Amanda G. Smith, J. Sonnen, S. Spina, P. George-Hyslop, R. Stern, R. Swerdlow, R. Tanzi, J. Troncoso, D. Tsuang, O. Valladares, V. V. Van Deerlin, L. V. Van Eldik, B. Vardarajan, H. Vinters, S. Weintraub, K. Welsh-Bohmer, K. Wilhelmsen, J. Williamson, T. Wingo, R. Woltjer, Clinton B. Wright, Chuang‐Kuo Wu, Chang-En Yu, Lei Yu, Yi Zhao   +192 more
semanticscholar   +1 more source

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

Molecular Brain, 2019
Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of materials for metabolic processes and ...
Bilal R. Malik, Daniel C. Maddison, Gaynor A. Smith, Owen M. Peters   +3 more
doaj   +1 more source

Microglia in action: how ageing and injury can change the brain's guardians

Frontiers in Cellular Neuroscience, 2015
Neuroinflammation, the inflammatory response in the CNS, is a major determinant of neuronal function and survival during ageing and disease progression.
Athanasios eLourbopoulos, Ali eErturk, Farida eHellal   +2 more
doaj   +1 more source

End-of-life care and dementia [PDF]

, 2006
In the UK, research continues to confirm that people with certain chronic illnesses, such as chronic lung disease and cardiac failure, represent the ‘disadvantaged dying’ compared to those with terminal cancer.
Ballard, Clive, Daley, Sarah, Hughes, Julian, Keady, John, Robinson, Louise, Volicer, Ladislav   +5 more
core   +1 more source

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

Alzheimer's & Dementia, 2020
Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late‐onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions ...
M. Kivipelto, F. Mangialasche, H. Snyder, R. Allegri, S. Andrieu, H. Arai, Laura D. Baker, S. Belleville, H. Brodaty, S. Brucki, I. Calandri, P. Caramelli, Christopher P. Chen, H. Chertkow, E. Chew, S. Choi, Neerja Chowdhary, L. Crivelli, R. Torre, Yifeng Du, T. Dua, M. Espeland, H. Feldman, M. Hartmanis, T. Hartmann, Megan Heffernan, C. Henry, C. H. Hong, K. Håkansson, T. Iwatsubo, J. Jeong, G. Jimenez-Maggiora, E. Koo, L. Launer, J. Lehtisalo, F. Lopera, P. Martínez-Lage, Ralph M. Martins, L. Middleton, J. Molinuevo, M. Montero‐Odasso, S. Moon, Kristal Morales-Pérez, R. Nitrini, H. Nygaard, Yoo Kyoung Park, M. Peltonen, C. Qiu, Y. Quiroz, R. Raman, Naren P Rao, V. Ravindranath, A. Rosenberg, T. Sakurai, R. M. Salinas, P. Scheltens, G. Sevlever, H. Soininen, A. Sosa, C. Suemoto, Mikel Tainta-Cuezva, L. Velilla, Yongxiang Wang, R. Whitmer, Xin Xu, L. Bain, A. Solomon, T. Ngandu, M. Carrillo   +68 more
semanticscholar   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source