Results 51 to 60 of about 1,350,087 (353)
Alzheimer’s Research & Therapy, 2020 Background Understanding the earliest manifestations of Alzheimer’s disease (AD) is key to realising disease-modifying treatments. Advances in neuroimaging and fluid biomarkers have improved our ability to identify AD pathology in vivo. The critical next
Antoinette O’Connor +9 more
doaj +1 more source
Awareness, requirements and barriers to use of Assistive Technology designed to enable independence of people suffering from Dementia (ATD) [PDF]
, 2012 This article is available through the Brunel Open Access Publishing Fund. Copyright @ 2012 IOS PressThis study investigated the awareness and use of assistive technology for people with dementia. The aim of the study was to explore barriers to the uptake
Jowitt, F +2 more
core +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
BMC Geriatrics, 2017 Background Dementia is a life-limiting condition that is increasing in global prevalence in line with population ageing. In this context, it is necessary to accurately measure dementia knowledge across a spectrum of health professional and lay ...
Michael J. Annear +5 more
doaj +1 more source
Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
FEBS Open Bio, EarlyView.Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro +8 more
wiley +1 more source
Reducing dementia risk by targeting modifiable risk factors in mid-life: study protocol for the Innovative midlife intervention for dementia deterrence (In-MINDD) randomised controlled feasibility trial [PDF]
, 2015 Background Dementia prevalence is increasing as populations live longer, with no cure and the costs of caring exceeding many other conditions. There is increasing evidence for modifiable risk factors which, if addressed in mid-life, can reduce the risk ...
Alex McConnachie +13 more
core +1 more source
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
Effect of therapeutic massage on pain in patients with dementia [PDF]
, 2016 Introduction The aim was to investigate whether therapeutic massage was effective in relieving pain in elderly residents with dementia. Methods A randomized controlled study was conducted in an aged care facility.
Kapoor, Yamini, Orr, Robin
core +1 more source
Alzheimer's & Dementia, 2021 At present, there is limited data on the risks, disparity, and outcomes for COVID‐19 in patients with dementia in the United States.
QuanQiu Wang +3 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan +46 more
wiley +1 more source