Results 51 to 60 of about 579,799 (311)

Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels

Journal of Neuroinflammation, 2023
Background Alzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and complement receptor 1 (CR1 ...
Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M. Zelek, Sarah M. Carpanini, Bryan Paul Morgan   +11 more
doaj   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks

Nature Communications
DNA-protein interactions have traditionally been profiled via chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq). Cleavage Under Targets & Tagmentation (CUT&Tag) is a rapidly expanding technique that enables the profiling of ...
Leyla Abbasova, Paulina Urbanaviciute, Di Hu, Joy N. Ismail, Brian M. Schilder, Alexi Nott, Nathan G. Skene, Sarah J. Marzi   +7 more
doaj   +1 more source

Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice

BMC Anesthesiology, 2018
Background There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer’s disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic ...
Adele Woodhouse, Carmen Maria Fernandez-Martos, Rachel Alice Kathryn Atkinson, Kelsey Anne Hanson, Jessica Marie Collins, Aidan Ryan O’Mara, Nico Terblanche, Marcus Welby Skinner, James Clement Vickers, Anna Elizabeth King   +9 more
doaj   +1 more source

Human iPSC-derived glia models for the study of neuroinflammation

Journal of Neuroinflammation, 2023
Neuroinflammation is a complex biological process that plays a significant role in various brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory responses in the central nervous system.
Nina Stöberl, Emily Maguire, Elisa Salis, Bethany Shaw, Hazel Hall-Roberts   +4 more
doaj   +1 more source

Psychometric Properties of the Clinical Dementia Rating — Sum of Boxes and other Cognitive and Functional Outcomes in a Prodromal Alzheimer's Disease Population [PDF]

, 2021
Fiona McDougall, Chris J. Edgar, Michaela Mertes, Paul Delmar, Paulo Fontoura, Danielle Abi‐Saab, C.J. Lansdall, Merçé Boada, Rachelle S. Doody   +8 more
openalex   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

Embedding Music and Music Therapy in Care Pathways for People with Dementia in the 21st Century—a position paper [PDF]

, 2021
Helen Odell‐Miller
openalex   +1 more source

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Development of a smartphone screening test for preclinical Alzheimer’s disease and validation across the dementia continuum

BMC Neurology
Background Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer’s disease (AD) constitutes 70% of cases. There is an urgent need to identify individuals with preclinical AD, a 10–20-year period of progressive brain ...
Jane Alty, Lynette R. Goldberg, Eddy Roccati, Katherine Lawler, Quan Bai, Guan Huang, Aidan D Bindoff, Renjie Li, Xinyi Wang, Rebecca J. St George, Kaylee Rudd, Larissa Bartlett, Jessica M. Collins, Mimieveshiofuo Aiyede, Nadeeshani Fernando, Anju Bhagwat, Julia Giffard, Katharine Salmon, Scott McDonald, Anna E. King, James C. Vickers   +20 more
doaj   +1 more source