Results 51 to 60 of about 1,330,157 (395)
Quantitative detection and staging of presymptomatic cognitive decline in familial Alzheimer’s disease: a retrospective cohort analysis
Alzheimer’s Research & Therapy, 2020 Background Understanding the earliest manifestations of Alzheimer’s disease (AD) is key to realising disease-modifying treatments. Advances in neuroimaging and fluid biomarkers have improved our ability to identify AD pathology in vivo. The critical next Antoinette O’Connor, Philip S. J. Weston, Ivanna M. Pavisic, Natalie S. Ryan, Jessica D. Collins, Kirsty Lu, Sebastian J. Crutch, Daniel C. Alexander, Nick C. Fox, Neil P. Oxtoby +9 moredoaj +1 more sourceWorld-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia
Alzheimer's & Dementia, 2020 Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late‐onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions ...M. Kivipelto, F. Mangialasche, H. Snyder, R. Allegri, S. Andrieu, H. Arai, Laura D. Baker, S. Belleville, H. Brodaty, S. Brucki, I. Calandri, P. Caramelli, Christopher P. Chen, H. Chertkow, E. Chew, S. Choi, Neerja Chowdhary, L. Crivelli, R. Torre, Yifeng Du, T. Dua, M. Espeland, H. Feldman, M. Hartmanis, T. Hartmann, Megan Heffernan, C. Henry, C. H. Hong, K. Håkansson, T. Iwatsubo, J. Jeong, G. Jimenez-Maggiora, E. Koo, L. Launer, J. Lehtisalo, F. Lopera, P. Martínez-Lage, Ralph M. Martins, L. Middleton, J. Molinuevo, M. Montero‐Odasso, S. Moon, Kristal Morales-Pérez, R. Nitrini, H. Nygaard, Yoo Kyoung Park, M. Peltonen, C. Qiu, Y. Quiroz, R. Raman, Naren P Rao, V. Ravindranath, A. Rosenberg, T. Sakurai, R. M. Salinas, P. Scheltens, G. Sevlever, H. Soininen, A. Sosa, C. Suemoto, Mikel Tainta-Cuezva, L. Velilla, Yongxiang Wang, R. Whitmer, Xin Xu, L. Bain, A. Solomon, T. Ngandu, M. Carrillo +68 moresemanticscholar +1 more sourceExceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
Nature Communications, 2020 Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes have a ...E. Reiman, Joseph F. Arboleda-Velasquez, Y. Quiroz, M. Huentelman, T. Beach, R. Caselli, Yinghua Chen, Yi Su, A. Myers, J. Hardy, Jean Paul Vonsattel, S. Younkin, D. Bennett, P. D. De Jager, E. Larson, P. Crane, C. Keene, M. Kamboh, J. Kofler, Linda Duque, J. Gilbert, H. Gwirtsman, J. Buxbaum, D. Dickson, M. Frosch, B. Ghetti, K. Lunetta, Li-San Wang, B. Hyman, W. Kukull, T. Foroud, J. Haines, R. Mayeux, M. Pericak-Vance, J. Schneider, J. Trojanowski, L. Farrer, G. Schellenberg, G. Beecham, T. Montine, G. Jun, Erin Perrie M. Marilyn S. Roger L. Liana G. Steven E. S Abner Adams Albert Albin Apostolova Arnold Asthana, E. Abner, P. Adams, M. Albert, R. Albin, L. Apostolova, S. Arnold, S. Asthana, C. Atwood, C. Baldwin, R. Barber, L. Barnes, S. Barral, J. Becker, D. Beekly, E. Bigio, T. Bird, D. Blacker, B. Boeve, J. Bowen, A. Boxer, J. Burke, J. Burns, N. Cairns, L. Cantwell, C. Cao, C. Carlson, C. Carlsson, R. Carney, M. Carrasquillo, H. Chui, D. Cribbs, E. Crocco, C. Cruchaga, C. DeCarli, M. Dick, R. Doody, R. Duara, N. Ertekin-Taner, Denis A. Evans, K. Faber, T. Fairchild, K. Fallon, D. Fardo, M. Farlow, S. Ferris, D. Galasko, M. Gearing, D. Geschwind, Valentina Ghisays, A. Goate, N. Graff-Radford, R. C. Green, J. Growdon, H. Hakonarson, R. Hamilton, K. Hamilton-Nelson, L. Harrell, L. Honig, R. Huebinger, C. Hulette, G. Jarvik, Lee‐way Jin, A. Karydas, M. Katz, J. Kauwe, J. Kaye, Ronald C. Kim, N. Kowall, J. Kramer, B. Kunkle, Amanda P. Kuzma, F. LaFerla, J. Lah, Y. Leung, J. Leverenz, A. Levey, Ge Li, A. Lieberman, R. Lipton, O. Lopez, C. Lyketsos, J. Malamon, D. Marson, E. Martin, F. Martiniuk, D. Mash, E. Masliah, W. McCormick, S. McCurry, A. McDavid, S. McDonough, A. Mckee, M. Mesulam, B. Miller, C. Miller, Joshua W. Miller, J. Morris, S. Mukherjee, A. Naj, S. O'Bryant, J. Olichney, J. Parisi, Hank Paulson, E. Peskind, Ronald Petersen, A. Pierce, W. Poon, H. Potter, L. Qu, J. Quinn, A. Raj, Murray M. Raskind, B. Reisberg, J. Reisch, C. Reitz, J. Ringman, E. Roberson, E. Rogaeva, H. Rosen, R. Rosenberg, D. Royall, M. Sager, M. Sano, A. Saykin, L. Schneider, W. Seeley, Amanda G. Smith, J. Sonnen, S. Spina, P. George-Hyslop, R. Stern, R. Swerdlow, R. Tanzi, J. Troncoso, D. Tsuang, O. Valladares, V. V. Van Deerlin, L. V. Van Eldik, B. Vardarajan, H. Vinters, S. Weintraub, K. Welsh-Bohmer, K. Wilhelmsen, J. Williamson, T. Wingo, R. Woltjer, Clinton B. Wright, Chuang‐Kuo Wu, Chang-En Yu, Lei Yu, Yi Zhao +192 moresemanticscholar +1 more sourceThe impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang +8 morewiley +1 more sourceImpact of dementia: Health disparities, population trends, care interventions, and economic costs
Journal of The American Geriatrics Society, 2021 The dementia experience is not a monolithic phenomenon—and while core elements of dementia are considered universal—people living with dementia experience the disorder differently. Understanding the patterning of Alzheimer's disease and related dementias M. Aranda, I. Kremer, L. Hinton, Julie Zissimopoulos, R. Whitmer, Cynthia Huling Hummel, L. Trejo, C. Fabius +7 moresemanticscholar +1 more sourceLewy Body Dementia Association\u27s Research Centers of Excellence Program: Inaugural Meeting Proceedings. [PDF]
, 2019 The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator\u27s meeting was held on December 14, 2017, in New Orleans.Amodeo, Katherine, Armstrong, Melissa, Barrett, Matt, Boeve, Brad, Christie, Tina, Domoto-Reilly, Kimiko, Duda, John, Galasko, Douglas, Galvin, James E., Goldman, Jennifer, Gomperts, Stephen, Graff-Radford, Neill, Graham, Todd, Holden, Samantha, Honig, Lawrence, Huddleston, Daniel, Irwin, David, Kaufer, Daniel, Koehler, Mike, Leverenz, James, Lippa, Carol, Litvan, Irene, Lunde, Angela, Manning, Carol, Marder, Karen, McKeith, Ian G., Moussa, Charbel, Onyike, Chiadi, Pagan, Fernando, Pantelyat, Alexander, Paulson, Henry, Pelak, Victoria, Peterson, Bethany, Poston, Kathleen, Quinn, Joseph, Richard, Irene, Richards, Ian, Rosenthal, Liana S., Sabbagh, Marwan, Scharre, Douglas, Sha, Sharon, Shill, Holly, Siderowf, Andrew, Taylor, Angela, Torres-Yaghi, Yasar +44 morecore +3 more sourcesTryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
FEBS Open Bio, EarlyView.Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell +8 morewiley +1 more source
