Results 41 to 50 of about 98,772 (389)

The role of demethylase AlkB homologs in cancer

Frontiers in Oncology, 2023
The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
doaj   +1 more source

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

Molecular Cancer, 2019
N6-methyladenosine (m6A) modification is the most pervasive modification in mRNA, and has been considered as a new layer of epigenetic regulation on mRNA processing, stability and translation.
Y. Niu, Ziyou Lin, Arabella H Wan, Honglei Chen, Heng-xing Liang, Lei Sun, Y. Wang, Xi Li, Xiao-Feng Xiong, Boxuan Wei, Xiaobin Wu, Guohui Wan   +11 more
semanticscholar   +1 more source

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
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Histone demethylase lysine demethylase 5B in development and cancer

Oncotarget, 2016
Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation status take part in various physiological and pathological processes.
Han, Mengjiao, Xu, Wenxia, Cheng, Pu, Jin, Hongchuan, Wang, Xian   +4 more
openaire   +3 more sources

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]

, 2020
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W, Geusz, Ryan J, Harrington, Austin R, Jhala, Ulupi S, Matta, Ileana, Patel, Nisha A, Rosenfeld, Michael G, Sander, Maike, Shih, Hung-Ping, Vinckier, Nicholas K, Wang, Allen, Wang, Jianxun, Wang, Jinzhao, Wetton, Nichole, Wortham, Matthew   +14 more
core   +2 more sources

H3K27 Demethylases, at Long Last [PDF]

Cell, 2007
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove ...
Swigut, Tomek, Wysocka, Joanna
openaire   +2 more sources

Allyl Aryl Ether Cleavage by Blautia sp. MRG-PMF1 Cocorrinoid O-Demethylase

Microbiology Spectrum, 2022
Coabalamin-dependent O-demethylase in Blautia sp. strain MRG-PMF1 was found to catalyze the unprecedented allyl aryl ether cleavage reaction. To expand the potential biotechnological applications, the reaction mechanism of the allyl aryl ether C-O bond ...
Huynh Thi Ngoc Mi, Santipap Chaiyasarn, Bekir Engin Eser, Steven R. Susanto Tan, Supawadee Burapan, Jaehong Han   +5 more
doaj   +1 more source

Histone Demethylase LSD1 Regulates Adipogenesis [PDF]

Journal of Biological Chemistry, 2010
Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type while maintaining the same genetic equipment.
Melina M, Musri, Mari Carmen, Carmona, Felicia A, Hanzu, Perla, Kaliman, Ramon, Gomis, Marcelina, Párrizas   +5 more
openaire   +2 more sources

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions

eLife, 2021
Active DNA demethylation has emerged as an important regulatory process of plant and mammalian immunity. However, very little is known about the mechanisms by which active demethylation controls transcriptional immune reprogramming and disease resistance.
T. Halter, Jingyu Wang, Delase Amesefe, Emmanuelle Lastrucci, M. Charvin, Meenu Singla Rastogi, Lionel Navarro   +6 more
semanticscholar   +1 more source