Results 21 to 30 of about 77,284 (302)
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]
, 2016 Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe +11 more
core +2 more sources
Biological and therapeutic role of LSD1 in Alzheimer’s diseases
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is a common chronic neurodegenerative disease characterized by cognitive learning and memory impairments, however, current treatments only provide symptomatic relief.
Yu Li +10 more
doaj +1 more source
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]
, 2020 Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W +14 more
core +2 more sources
JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. [PDF]
, 2016 JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells.
Bai, Nan +10 more
core +1 more source
Histone demethylase lysine demethylase 5B in development and cancer
Oncotarget, 2016 Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation status take part in various physiological and pathological processes.
Han, Mengjiao +4 more
openaire +3 more sources
H3K27 Demethylases, at Long Last [PDF]
Cell, 2007 Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove ...
Swigut, Tomek, Wysocka, Joanna
openaire +2 more sources
Frontiers in Genetics, 2018 Post-translational modification of histones, such as histone methylation controlled by specific methyltransferases and demethylases, play critical roles in modulating chromatin dynamics and transcription in eukaryotes.
Yani Zheng +9 more
doaj +1 more source
Allyl Aryl Ether Cleavage by Blautia sp. MRG-PMF1 Cocorrinoid O-Demethylase
Microbiology Spectrum, 2022 Coabalamin-dependent O-demethylase in Blautia sp. strain MRG-PMF1 was found to catalyze the unprecedented allyl aryl ether cleavage reaction. To expand the potential biotechnological applications, the reaction mechanism of the allyl aryl ether C-O bond ...
Huynh Thi Ngoc Mi +5 more
doaj +1 more source
Histone Demethylase LSD1 Regulates Adipogenesis [PDF]
Journal of Biological Chemistry, 2010 Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type while maintaining the same genetic equipment.
Melina M, Musri +5 more
openaire +2 more sources
Balkan Medical Journal, 2022 Background: Diffuse large B-cell lymphoma is a type of B-cell non-Hodgkin lymphoma with a high incidence. About one-third of patients are resistant or eventually relapse.
YuYing Cui +6 more
doaj +1 more source