Results 41 to 50 of about 47,850 (262)

Genome-wide identification and characterization of ALKB homolog gene family in wheat (Triticum aestivum L.)

Frontiers in Plant Science
IntroductionN6-methyladenosine (m6A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. AlkB homologs (ALKBHs) are involved in plant responses to stress by modulating m6A methylation.
Pengkun Wang, Tianye Zhang, Zechi Wu, Lei Yu, Pingan Liao, Jian Yang, Bingjian Sun   +6 more
doaj   +1 more source

Histone Lysine Demethylase Inhibitors [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar, Jamie N, Anastas, Yang, Shi   +2 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Identification and characterization of PKF118-310 as a KDM4A inhibitor

Epigenetics, 2017
Epigenetic modifications are functionally involved in gene expression regulation. In particular, histone posttranslational modifications play a crucial role in functional chromatin organization. Several drugs able to inhibit or stimulate some families of
Gianluigi Franci, Federica Sarno, Angela Nebbioso, Lucia Altucci   +3 more
doaj   +1 more source

Effects of Cyclamen trochopteranthum on hepatic drug-metabolizing enzymes [PDF]

Archives of Biological Sciences, 2011
The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A ...
Arslan Sevki, Ozgun Ozden, Celik Gurbet, Semiz Asli, Dusen Olcay, Mammadov Ramazan, Sen Alaattin   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Genome-wide identification and expression analysis of DNA demethylase family in cotton

Journal of Cotton Research, 2019
Background DNA methylation is an important epigenetic factor that maintains and regulates gene expression. The mode and level of DNA methylation depend on the roles of DNA methyltransferase and demethylase, while DNA demethylase plays a key role in the ...
Xiaomin YANG, Xuke LU, Xiugui CHEN, Delong WANG, Junjuan WANG, Shuai WANG, Lixue GUO, Chao CHEN, Xiaoge WANG, Xinlei WANG, Wuwei YE   +10 more
doaj   +1 more source

Targeting epigenetic regulators to overcome drug resistance in cancers

Signal Transduction and Targeted Therapy, 2023
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source