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Cuprizone feed formulation influences the extent of demyelinating disease pathology [PDF]
Scientific Reports, 2021 Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals ingesting ...
Lillian M. Toomey +9 more
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Central nervous system Cryptococcoma mimicking demyelinating disease: a case report [PDF]
BMC Neurology, 2020 Background Cerebral cryptococcomas is a rare form of central nervous system cryptococcosis. Most previous cases were mistaken for neoplasm before surgery.
Jie Wei, Xiang-Yu Li, Yue Zhang
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Neuroradiological evaluation of demyelinating disease [PDF]
Therapeutic Advances in Neurological Disorders, 2013 Central nervous system inflammatory demyelinating disease can affect patients across the life span. Consensus definitions and criteria of all of the different acquired demyelinating diseases that fall on this spectrum have magnetic resonance imaging ...
Jan-Mendelt Tillema, Istvan Pirko
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Atypical demyelinating disease [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1974 A 17 year old girl died after an illness characterized by progressive mental deterioration and severe myoclonic jerks. Extensive pathological, virological, and immunological studies failed to support the diagnosis of subacute sclerosing panencephalitis but were compatible with disseminated demyelinating disease.
John M. Adams +5 more
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Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease. [PDF]
PLoS ONE, 2017 Infection of various cells with Theiler's murine encephalomyelitis virus (TMEV) activates the TLR- and melanoma differentiation-associated gene 5 (MDA5)-dependent pathways, resulting in the production of IL-1β via the activation of caspase-1 upon ...
Seung Jae Kim +2 more
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Endothelin-1 contributes to the development of virus-induced demyelinating disease [PDF]
Journal of Neuroinflammation, 2020 Background Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis.
Young-Hee Jin +4 more
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Frontiers in Genetics, 2019 Exosomes can pass through the blood-brain barrier and are present in the cerebrospinal fluid (CSF). The components in exosomes, such as DNA, RNA, protein, and lipids, change greatly and are closely related to disease progression.
Jinting He +6 more
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Case Report: TNF-α Inhibitor-Associated Demyelinating Disease [PDF]
Journal of Investigative Medicine High Impact Case ReportsTumor necrosis factor-alpha inhibitors (TNF-αi’s) such as Infliximab are effective treatments for various autoimmune diseases. However, in rare instances, they have been implicated in central nervous system demyelination.
Christopher Tuohino BS, Trevor Cline MD
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Cell therapy in demyelinating diseases [PDF]
Neurotherapeutics, 2004 Multiple sclerosis presents particular and serious problems to those attempting to develop cell-based therapies: the occurrence of innumerable lesions scattered throughout the CNS, axon loss, astrocytosis, and a continuing inflammatory process, to name but a few.
Claire M Rice +2 more
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Akt3-Mediated Protection Against Inflammatory Demyelinating Disease
Frontiers in Immunology, 2019 Akt is a serine/threonine protein kinase that plays a major role in regulating multiple cellular processes. While the isoforms Akt1 and Akt2 are involved in apoptosis and insulin signaling, respectively, the role for Akt3 remains uncertain.
Juwen C. DuBois +6 more
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