Results 1 to 10 of about 50 (48)

Demyelination in rheumatic diseases [PDF]

open access: yesPostgraduate Medical Journal, 2008
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterised by multifocal areas of demyelination in the white matter of the brain and spinal cord. Autoantibodies, for example antinuclear antibodies, can also be present.
A Theodoridou, Loukas Settas
openaire   +4 more sources

Macrophages and Autoantibodies in Demyelinating Diseases [PDF]

open access: yesCells, 2021
Myelin phagocytosis by macrophages has been an essential feature of demyelinating diseases in the central and peripheral nervous systems, including Guillain–Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multiple sclerosis (MS). The discovery of autoantibodies, including anti-ganglioside GM1 antibodies in the axonal
Haruki Koike, Masahisa Katsuno
openaire   +4 more sources

Atypical demyelinating disease [PDF]

open access: yesJournal of Neurology, Neurosurgery & Psychiatry, 1974
A 17 year old girl died after an illness characterized by progressive mental deterioration and severe myoclonic jerks. Extensive pathological, virological, and immunological studies failed to support the diagnosis of subacute sclerosing panencephalitis but were compatible with disseminated demyelinating disease.
J. M. Adams   +5 more
openaire   +3 more sources

Demyelinating diseases [PDF]

open access: yesJournal of Clinical Pathology, 2006
A diagnosis of demyelination carries important therapeutic and prognostic implications. In most cases the diagnosis is made clinically, and involvement of the histopathologist is largely confined to postmortem confirmation and clinicopathological correlation.
openaire   +3 more sources

Fulminant Demyelinating Diseases [PDF]

open access: yesThe Neurohospitalist, 2013
Fulminant demyelinating disease is a heading that covers acute disseminated encephalomyelitis and its variant acute hemorrhagic leukoencephalitis (Hurst disease), severe relapses of multiple sclerosis (MS), variants of MS (tumefactive MS, Marburg variant, Balo concentric sclerosis, myelinoclastic diffuse sclerosis), and neuromyelitis optica-spectrum ...
Orhun H. Kantarci, Megan R. Rahmlow
openaire   +3 more sources

Anaesthesia and demyelinating disease [PDF]

open access: yesAnaesthesia, 1980
SummaryThe demyelinating diseases are classified and the current concepts of the aetiology and pathophysiology of the most common of these diseases, multiple sclerosis, are described. The effects of the impaired function, local responses and known complications of the disease on the choice of anaesthetic, drugs and techniques are discussed.
T. E. J. Healy, Ronald M. Jones
openaire   +3 more sources

Cell therapy in demyelinating diseases [PDF]

open access: yesNeurotherapeutics, 2004
Multiple sclerosis presents particular and serious problems to those attempting to develop cell-based therapies: the occurrence of innumerable lesions scattered throughout the CNS, axon loss, astrocytosis, and a continuing inflammatory process, to name but a few.
CA Halfpenny   +3 more
openaire   +3 more sources

Glial grafting for demyelinating disease [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2005
Remyelination of demyelinated central nervous system (CNS) axons is considered as a potential treatment for multiple sclerosis, and it has been achieved in experimental models of demyelination by transplantation of pro-myelinating cells. However, the experiments undertaken have not addressed the need for tissue-type matching in order to achieve graft ...
W. F. Blakemore, Vanja Tepavcevic
openaire   +2 more sources

The virology of demyelinating diseases [PDF]

open access: yesAnnals of Neurology, 1994
Infectious agents have been postulated as causes of multiple sclerosis for over a century. The possible role of a virus or viruses is supported by data that (1) a childhood exposure is involved and "viral" infections may precipitate exacerbations of disease, (2) experimental infections in animals and natural infections in humans can cause diseases with
openaire   +3 more sources

Neuroradiological evaluation of demyelinating disease [PDF]

open access: yesTherapeutic Advances in Neurological Disorders, 2013
Central nervous system inflammatory demyelinating disease can affect patients across the life span. Consensus definitions and criteria of all of the different acquired demyelinating diseases that fall on this spectrum have magnetic resonance imaging criteria.
Jan Mendelt Tillema, Istvan Pirko
openaire   +3 more sources

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