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The Biochemistry of Demyelination and Demyelinating Diseases
1972Wallerian degeneration was the first experimental model of demyelination devised and has been widely investigated both structurally and biochemically. After severing a peripheral nerve there is increasing loss of cerebrosides, sphingomyelin, cholesterol and phospholipids, that of the cephalins starting earlier and exceeding that of lecithin [1]. During
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Demyelination in peroxisomal diseases
Journal of the Neurological Sciences, 2005Peroxisomal disorders that display neurologic involvement usually show a variety of abnormalities in white matter of the central nervous system (CNS). Adult Refsum’s disease primarily exhibits a hypertrophic (onion bulb) demyelinating neuropathy. The changes in CNS white matter vary greatly between these diseases, but basically can be divided into ...
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2004
Abstract Demyelinating diseases share the common pathologic feature of foci of degeneration, involving the myelin sheath of nervous tissue. Multiple sclerosis (MS) is the commonest demyelinating disease and this chapter will focus on the palliative management of MS.
Fabio Formaglio, A D (Sandy) Macleod
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Abstract Demyelinating diseases share the common pathologic feature of foci of degeneration, involving the myelin sheath of nervous tissue. Multiple sclerosis (MS) is the commonest demyelinating disease and this chapter will focus on the palliative management of MS.
Fabio Formaglio, A D (Sandy) Macleod
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Peripheral Inflammation and Demyelinating Diseases
2016In recent decades, several neurodegenerative diseases have been shown to be exacerbated by systemic inflammatory processes. There is a wide range of literature that demonstrates a clear but complex relationship between the central nervous system (CNS) and the immunological system, both under naïve or pathological conditions.
Murta, Verónica, Ferrari, Carina Cintia
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2001
Abstract In contrast to dysmyelination, demyelination refers to a stripping away of myelin from the axon. The demyelinative diseases target the normal myelin only after it is fully formed, and these diseases are characterized by an inflammatory attack on the myelin sheath. The most familiar demyelinative disease is multiple sclerosis (MS)
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Abstract In contrast to dysmyelination, demyelination refers to a stripping away of myelin from the axon. The demyelinative diseases target the normal myelin only after it is fully formed, and these diseases are characterized by an inflammatory attack on the myelin sheath. The most familiar demyelinative disease is multiple sclerosis (MS)
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Selective Depletion of Antigen-Specific Antibodies for the Treatment of Demyelinating Disease
Molecular Therapy, 2021Raimund Ober, Benjamin Greenberg
exaly