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2001
Abstract In contrast to dysmyelination, demyelination refers to a stripping away of myelin from the axon. The demyelinative diseases target the normal myelin only after it is fully formed, and these diseases are characterized by an inflammatory attack on the myelin sheath. The most familiar demyelinative disease is multiple sclerosis (MS)
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Abstract In contrast to dysmyelination, demyelination refers to a stripping away of myelin from the axon. The demyelinative diseases target the normal myelin only after it is fully formed, and these diseases are characterized by an inflammatory attack on the myelin sheath. The most familiar demyelinative disease is multiple sclerosis (MS)
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Pathology and pathogenesis of demyelinating diseases
Current Opinion in Neurology, 1997Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system of putative autoimmune origin. In the present review the hypothesis that autoimmunity against multiple different brain antigens can lead to T-cell mediated brain inflammation and that multiple different immunological mechanisms may be responsible for the ...
Hans Lassmann, Maria K. Storch
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Acute and Chronic Demyelinating Disease
Otolaryngologic Clinics of North America, 1987There are multiple entities subsumed under this title that have in common the primary destruction of central nervous system myelin with relative sparing of axons. The hereditary diseases are often referred to as dysmyelinating diseases in which there is a genetic defect in the formation or maintenance of myelin; they usually occur in children.
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Demyelinating Disease: Evolution of a Paradigm
Neurochemical Research, 1999Multiple sclerosis was at one time viewed as a spiritual (God-given) disorder; only much later was it recognized as a scarring process. With advancing scientific knowledge, it was seen as a primarily demyelinating disease, later as thromboembolic in origin, and finally as inflammatory and destructive, probably an immunologic response to exogenous ...
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Cytokines in Demyelinating Diseases
2008Abstract Among the autoimmune diseases, multiple sclerosis (MS) has been up to now best understood with regard to the pathogenesis of inflammation and demyelination, which affects the white matter of the brain. In MS brain are founded focal infiltrates of T cells and macrophages, axonal injury, and loss of neurological functions 1 , 2 , 3 .
Natalia M. Kalinina +1 more
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PATHOPHYSIOLOGY OF DEMYELINATING DISEASE [PDF]
British Medical Bulletin, 1977 A M Halliday, W I McDonald
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Mitochondrial Dysfunction in Demyelinating Diseases
Seminars in Pediatric Neurology, 2013Dysfunction of the mitochondrial (mt) system is thought to play an important role in the mechanism of progression of various neurodegenerative disorders, including demyelinating disorders. They are characterized by neuroinflammation, ultimately leading to neurodegeneration.
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