Results 81 to 90 of about 388,663 (309)

The hydrophobic effect and its role in cold denaturation

, 2010
The hydrophobic effect is considered the main driving force for protein folding and plays an important role in the stability of those biomolecules.
Dias, C.L., Ala-Nissila, T., Vattulainen, I., Grant, M., Wong-ekkabut, J., Karttunen, M.E.J., Cristiano L. Dias, Mikko Karttunen, Jirasak Wong-ekkabut, Martin Grant, Ilpo Vattulainen, Tapio Ala-Nissila   +11 more
core   +1 more source

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source

Denaturation of HIV-1 Protease (PR) monomer by acetic acid: mechanistic and trajectory insights from molecular dynamics simulations and NMR

, 2012
Inside a living cell there can be a variety of interactions for any given protein, which serve to regulate denaturation and renaturation processes. Insights into some of them can be obtained by in vitro studies using various denaturing agents.
Rout, Manoj Kumar, Hosur, Ramakrishna V., Borkar, Aditi   +2 more
core   +1 more source

Thermal denaturation.

, 2013
Ellipticity (A & B) and emission (C & D) measurement of CpGAL as a function of temperature. Emission shows monotonous decrease in the intensity of λmax with increasing temperature.
Devesh Kishore (150318), Arvind M. Kayastha (150333), Suman Kundu (199925)   +2 more
core   +1 more source

Rationally engineered polymeric interfaces for selective and dynamic recognition of vesicular agents

FEBS Open Bio, EarlyView.
This review explores how molecularly imprinted polymers can be engineered to recognize complex nanoscale vesicles, including extracellular vesicles and membrane‐enveloped viruses. By tailoring polymer cavities to vesicle surface chemistry and structure, these synthetic receptors support selective detection, separation, and integration with optical ...
Özgecan Erdem, Eylul Gulsen Yilmaz, Selcan Genc, Nil Kılıç, Fatih Inci   +4 more
wiley   +1 more source

Molecular Dynamics of Protein Denaturation by Urea [PDF]

, 2020
The project will be focused on the denaturation of proteins by urea. It will be conducted using computer simulations, where four selected proteins, including 4bir, 3bov, 2vim, and 2yxf, were set into a 130 x 130 x 130 A3 water box filled with 8M of urea ...
Nguyen, Amita P
core   +1 more source

Potential effect of human chorionic gonadotropin‐induced extracellular vesicle RNAs on mouse ovarian granulosa cells

FEBS Open Bio, EarlyView.
To mimic the LH action in the ovary, granulosa‐cell and mouse models were stimulated by hCG, which changed RNA profiles within extracellular vesicles (EVs), and potentially hCG‐responsive EV RNAs increased the number of recipient ovarian cells. EV‐associated RNAs are potential intermediaries of hCG signaling.
Natchanok Puangjit, Nobuhiko Takahashi, Yuki Maruyama, Shota Mayama, Katsueki Ogiwara, Chika Fujimori, Atsushi P. Kimura   +6 more
wiley   +1 more source

Chemical shifts in denatured proteins: Resonance assignments for denatured ubiquitin and comparisons with other denatured proteins

Journal of Biomolecular NMR, 2001
Chemical shift assignment is reported for the protein ubiquitin denatured in 8M urea at pH 2. The variations in 15N chemical shifts of three different proteins (ubiquitin, disulfide reduced, carboxymethylated lysozyme, all-Ala-alpha-lactalbumin), all without disulfides and denatured in 8M urea at pH 2 are compared to 'random coil shifts' of small model
Peti, W, Smith, L, Redfield, C, Schwalbe, H   +3 more
openaire   +3 more sources

The cold denaturation of IscU highlights structure–function dualism in marginally stable proteins [PDF]

, 2018
Proteins undergo both cold and heat denaturation, but often cold denaturation cannot be detected because it occurs at temperatures below water freezing.
DeLos Rios, Paolo, Pastore, Annalisa; id_orcid, De Los Rios, Paolo, Paolo DeLos Rios, Piero Andrea Temussi, Pastore, Annalisa, Temussi, Piero Andrea, Yan, Robert, Annalisa Pastore, Temisso, Piero Andrea, Robert Yan   +10 more
core   +2 more sources

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source