Results 91 to 100 of about 131,881 (286)

Chemical analysis and protective effect of Elaeis guineensis kernel oil against calcium ion-induced mitochondrial membrane permeability transition

Journal of Basic and Applied Research in Biomedicine, 2022
This study evaluated the chemical property and effect of Elaeis guineensis kernel (EGK) oil on calcium ion-induced mitochondrial membrane permeability transition (MMPT) using standard in vitro methods. Results showed the EGK oil values for iodine (46.53±
God’swill Anyasor, Ezinwanne Onuoha, Gisarin Olusola   +2 more
doaj   +2 more sources

Thermal stability of pepsin: A predictive thermodynamic model of a multi-domain protein

Biochemistry and Biophysics Reports, 2017
Pepsin is generally used in the preparation of F(ab)2 fragments from antibodies. The antibodies that are one of the largest and fastest growing categories of bio- pharmaceutical candidates.
Ali Asghar Rastegari, Behnaz Buzari, Abdol-Khalegh Bordbar   +2 more
doaj   +1 more source

Multi-Step Unfolding and Rearrangement of α-Lactalbumin by SDS Revealed by Stopped-Flow SAXS

Frontiers in Molecular Biosciences, 2020
Interactions between proteins and surfactants are both of fundamental interest and relevant for applications in food, cosmetics and detergency. The anionic surfactant sodium dodecyl sulfate (SDS) denatures essentially all proteins. Denaturation typically
Grethe Vestergaard Jensen, Grethe Vestergaard Jensen, Jannik Nedergaard Pedersen, Daniel E. Otzen, Daniel E. Otzen, Jan Skov Pedersen, Jan Skov Pedersen   +6 more
doaj   +1 more source

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Multiple timescales in a model for DNA denaturation dynamics [PDF]

, 2009
The denaturation dynamics of a long double-stranded DNA is studied by means of a model of the Poland-Scheraga type. We note that the linking of the two strands is a locally conserved quantity, hence we introduce local updates that respect this symmetry ...
Alberts B, Blake R D, de Gennes P G, Dean F B, Drukker K, Duke T A J, Hanke A, Kabakçıoğlu A Orlandini E Mukamel D, Kafri Y, Kunz H, Marco Baiesi, Novotny T, Paul W, Peyrard M, Poland D, Roberto Livi, Rubinstein M, van Heukelum A, Wartell R M   +18 more
core   +1 more source

Smoothening of Depinning Transitions for Directed Polymers with Quenched Disorder

, 2006
We consider disordered models of pinning of directed polymers on a defect line, including (1+1)-dimensional interface wetting models, disordered Poland--Scheraga models of DNA denaturation and other (1+d)-dimensional polymers in interaction with columnar
C. Monthus, F. L. Toninelli, G. Giacomin, T. Garel   +3 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Thermal stability of human matrix metalloproteinases

Heliyon, 2020
Matrix metalloproteinases (MMP) are key players in the remodelling of the extracellular matrix under physiological and pathological conditions. Thermodynamic parameters of human recombinant metalloproteinases of the active (rMMP2, 3, 7, 8 and 9) and ...
Noemi Meraz-Cruz, Felipe Vadillo-Ortega, Aura M. Jiménez-Garduño, Alicia Ortega   +3 more
doaj   +1 more source

Low-Temperature and High-Pressure Induced Swelling of a Hydrophobic Polymer-Chain in Aqueous Solution

, 2005
We report molecular dynamics simulations of a hydrophobic polymer-chain in aqueous solution between $260 {K}$ and $420 {K}$ at pressures of $1 {bar}$, $3000 {bar}$, and $4500 {bar}$.
Alfons Geiger, Berendsen, Blokzijl, Brandts, Daggett, De Los Rios, De Los Rios, Dietmar Paschek, Essmann, Flyvbjerg, Forsman, Geiger, Ghosh, Ghosh, Ghosh, Ghosh, Hawley, Herberhold, Herberhold, Hoover, Huang, Hummer, Lindahl, Lüdemann, Lüdemann, Mahoney, Marqués, Miyamoto, Moghaddam, Muller, Naghibi, Neumann, Nicolini, Nosé, Nosé, Pangali, Panick, Parrinello, Paschek, Paschek, Payne, Pearlman, Peng, Pratt, Privalov, Privalov, Ravindra, Rein ten Wolde, Rettich, Rick, Rick, Rick, Roberts, Roberts, Royer, Ryckaert, Sascha Nonn, Shimizu, Shimizu, Shimizu, Silva, Silva, Silverstein, Skipper, Smeller, Smith, Smith, Southall, Wilhelm, Zichi, Zipp   +70 more
core   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source