Results 41 to 50 of about 3,898 (197)

MAP2 phosphorylation: mechanisms, functional consequences, and emerging insights

Frontiers in Cellular Neuroscience
Microtubule-associated protein 2 (MAP2) is a key regulator of cytoskeletal dynamics and neuronal function. It stabilizes microtubules, shapes dendrites, influences synaptic plasticity, and regulates transportation and protein synthesis through its ...
Jiali Lyu, Jiali Lyu, Andrew G. DeMarco, Robert A. Sweet, Robert A. Sweet, Robert A. Sweet, Melanie J. Grubisha, Melanie J. Grubisha   +7 more
doaj   +1 more source

Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN

eLife, 2021
Hypothalamic oxytocinergic magnocellular neurons have a fascinating ability to release peptide from both their axon terminals and from their dendrites.
Wanhui Sheng, Scott W Harden, Yalun Tan, Eric G Krause, Charles J Frazier   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Cell-autonomous reduction of CYFIP2 changes dendrite length, dendritic protrusion morphology, and inhibitory synapse density in the hippocampal CA1 pyramidal neurons of 17-month-old mice

Animal Cells and Systems
The cytoplasmic FMR1-interacting protein 2 (CYFIP2) have diverse molecular functions in neurons, including the regulation of actin polymerization, mRNA translation, and mitochondrial morphology and function.
Yoonhee Kim, Ruiying Ma, Yinhua Zhang, Hyae Rim Kang, U Suk Kim, Kihoon Han   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.

PLoS Genetics
Most neurons are not replaced after injury and thus possess robust intrinsic mechanisms for repair after damage. Axon injury triggers a calcium wave, and calcium and cAMP can augment axon regeneration.
J Ian Hertzler, Jiajing Teng, Annabelle R Bernard, Michelle C Stone, Hannah L Kline, Gibarni Mahata, Nitish Kumar, Melissa M Rolls   +7 more
doaj   +1 more source

L-Type Voltage-Gated Ca2+ Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites

Cell Reports, 2017
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane.
Brian G. Hiester, Ashley M. Bourke, Brooke L. Sinnen, Sarah G. Cook, Emily S. Gibson, Katharine R. Smith, Matthew J. Kennedy   +6 more
doaj   +1 more source

Patterning of dendritic territories by dendrite-dendrite and dendrite-substrate interactions

, 2014
Dendrites develop in highly complex environments and their interactions with neighboring neurons and the substrate are thought to be important for the establishment of their dendritic territories. Mechanisms required for the establishment of dendritic territories remain largely elusive.
openaire   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Influence of the type of electrolyte on the morphological and crystallographic characteristics of lead powder particles [PDF]

Journal of the Serbian Chemical Society, 2013
Lead electrodeposition processes from the basic (nitrate) and complex (acetate) electrolytes were mutually compared by the scanning electron microscopic and the X-ray diffraction analysis of the produced powder particles.
Nikolić Nebojša D., Maksimović Vesna M., Branković Goran, Živković Predrag M., Pavlović Miomir G.   +4 more
doaj   +1 more source