Results 61 to 70 of about 118,530 (311)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease

Scientific Reports
Dendrite defects and loss are early cellular alterations observed across neurodegenerative diseases that play a role in early disease pathogenesis.
Sydney E. Prange, Isha N. Bhakta, Daria Sysoeva, Grace E. Jean, Anjali Madisetti, Hieu H. N. Le, Ly U. Duong, Patrick T. Hwu, Jaela G. Melton, Katherine L. Thompson-Peer   +9 more
doaj   +1 more source

Improvements in Simultaneous Sodium and Calcium Imaging

Frontiers in Cellular Neuroscience, 2019
High speed imaging of ion concentration changes in neurons is an important and growing tool for neuroscientists. We previously developed a system for simultaneously measuring sodium and calcium changes in small compartments in neurons (Miyazaki and Ross,
Kenichi Miyazaki, Kenichi Miyazaki, John E. Lisman, John E. Lisman, William N. Ross, William N. Ross   +5 more
doaj   +1 more source

Dendrite-Free Lithium Anode Enables the Lithium//Graphite Dual-Ion Battery with Much Improved Cyclic Stability

, 2018
Owing to the high de/intercalation potential of anions on graphite cathode, dual-ion battery (DIB) has attracted much attention for advanced energy storage.
Wen-Hao Li (4778280), Xiao-Tong Xi (6088763), Zhen-Yi Gu (5219195), Xing-Long Wu (1401565), Yang Yang (45629), Bao-Hua Hou (4778286)   +5 more
core   +1 more source

Avoiding Dendrite Formation by Confining Lithium Deposition Underneath Li-Sn Coatings

, 2020
The use of interfacial layers to stabilize the lithium surface is a popular research direction for improving the morphology of deposited lithium and suppressing lithium dendrite formation.
Qizhang, Yan, Jian, Luo, Grace, Whang, Philippe, Sautet, Da, Li, Ziyang, Wei, Bruce S., dunn, Danielle M., Butts   +7 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Modeling of dendrite arm fragmentation and dendrite arm coarsening

, 2020
A two-dimensional quantitative cellular automaton (CA) model is employed to simulate dendrite arm fragmentation and dendrite arm coarsening in mushy zones.
Shiyan Pan, Hua Xue, Hui Fang, Qingyu Zhang, Mingfang Zhu, Mengdan Hu   +5 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source