Results 51 to 60 of about 3,898 (197)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity

eLife
Dendritic branching and synaptic organization shape single-neuron and network computations. How they emerge simultaneously during brain development as neurons become integrated into functional networks is still not mechanistically understood.
Jan H Kirchner, Lucas Euler, Ingo Fritz, André Ferreira Castro, Julijana Gjorgjieva   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Type-specific molecular signaling architectures and synaptic plasticity of Drosophila olfactory sensory neurons

Frontiers in Cellular Neuroscience
Olfactory sensory neurons (OSNs) detect odours at a wide range of intensities. In Drosophila, volatile compounds bind to specific odorant receptors (ORs), which tune the sensitivity of chemoreception.
Namrata Acharya, Eric Wiesel, Mareike Selcho, Nadine Ehmann, Marius Lamberty, Bill S. Hansson, Dieter Wicher, Robert J. Kittel   +7 more
doaj   +1 more source

Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism

Frontiers in Neuroscience, 2020
Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD).
Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Atsuko Hayata-Takano, Takanobu Nakazawa, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Shinsaku Nakagawa, Shinsaku Nakagawa, Kazuhiro Takuma, Kazuhiro Takuma, James A. Waschek, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Yukio Ago, Yukio Ago, Yukio Ago, Yukio Ago   +27 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Basal Dendritic Morphology of Cortical Pyramidal Neurons in Williams Syndrome: Prefrontal Cortex and Beyond

Frontiers in Neuroscience, 2017
Williams syndrome (WS) is a unique neurodevelopmental disorder with a specific behavioral and cognitive profile, which includes hyperaffiliative behavior, poor social judgment, and lack of social inhibition.
Branka Hrvoj-Mihic, Kari L. Hanson, Caroline H. Lew, Lisa Stefanacci, Bob Jacobs, Ursula Bellugi, Katerina Semendeferi, Katerina Semendeferi   +7 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

In Situ Formed Three‐Dimensionally Conducting Polymer Electrolyte for Solid‐State Lithium Metal Batteries With High‐Cathode Loading

SusMat
Low‐ionic conductivity within high‐loading cathode has greatly limited the application of solid polymer electrolytes in rechargeable batteries. Herein, solid polymer electrolyte with a three‐dimensionally conducting network is obtained by in situ ...
Zhi‐Wei Dong, Yun‐Fei Du, Mei Geng, Jia‐Xin Guo, Xin Shen, Wen‐Bo Tang, Kai Chen, Li‐Feng Chen, Xiao‐Song Liu, Xin‐Bing Cheng   +9 more
doaj   +1 more source

ShuTu: Open-Source Software for Efficient and Accurate Reconstruction of Dendritic Morphology

Frontiers in Neuroinformatics, 2019
Neurons perform computations by integrating inputs from thousands of synapses—mostly in the dendritic tree—to drive action potential firing in the axon. One fruitful approach to studying this process is to record from neurons using patch-clamp electrodes,
Dezhe Z. Jin, Ting Zhao, David L. Hunt, Rachel P. Tillage, Ching-Lung Hsu, Nelson Spruston   +5 more
doaj   +1 more source