Results 51 to 60 of about 102,682 (267)

L-Type Voltage-Gated Ca2+ Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites

Cell Reports, 2017
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane.
Brian G. Hiester, Ashley M. Bourke, Brooke L. Sinnen, Sarah G. Cook, Emily S. Gibson, Katharine R. Smith, Matthew J. Kennedy   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Influence of the type of electrolyte on the morphological and crystallographic characteristics of lead powder particles [PDF]

Journal of the Serbian Chemical Society, 2013
Lead electrodeposition processes from the basic (nitrate) and complex (acetate) electrolytes were mutually compared by the scanning electron microscopic and the X-ray diffraction analysis of the produced powder particles.
Nikolić Nebojša D., Maksimović Vesna M., Branković Goran, Živković Predrag M., Pavlović Miomir G.   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease

Scientific Reports
Dendrite defects and loss are early cellular alterations observed across neurodegenerative diseases that play a role in early disease pathogenesis.
Sydney E. Prange, Isha N. Bhakta, Daria Sysoeva, Grace E. Jean, Anjali Madisetti, Hieu H. N. Le, Ly U. Duong, Patrick T. Hwu, Jaela G. Melton, Katherine L. Thompson-Peer   +9 more
doaj   +1 more source

Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity

eLife
Dendritic branching and synaptic organization shape single-neuron and network computations. How they emerge simultaneously during brain development as neurons become integrated into functional networks is still not mechanistically understood.
Jan H Kirchner, Lucas Euler, Ingo Fritz, André Ferreira Castro, Julijana Gjorgjieva   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Type-specific molecular signaling architectures and synaptic plasticity of Drosophila olfactory sensory neurons

Frontiers in Cellular Neuroscience
Olfactory sensory neurons (OSNs) detect odours at a wide range of intensities. In Drosophila, volatile compounds bind to specific odorant receptors (ORs), which tune the sensitivity of chemoreception.
Namrata Acharya, Eric Wiesel, Mareike Selcho, Nadine Ehmann, Marius Lamberty, Bill S. Hansson, Dieter Wicher, Robert J. Kittel   +7 more
doaj   +1 more source

Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism

Frontiers in Neuroscience, 2020
Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD).
Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Atsuko Hayata-Takano, Takanobu Nakazawa, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Shinsaku Nakagawa, Shinsaku Nakagawa, Kazuhiro Takuma, Kazuhiro Takuma, James A. Waschek, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Yukio Ago, Yukio Ago, Yukio Ago, Yukio Ago   +27 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source