Results 51 to 60 of about 165,498 (276)
Growth Factors as Axon Guidance Molecules: Lessons From in vitro Studies
Frontiers in Neuroscience, 2021 Growth cones at the tips of extending axons navigate through developing organisms by probing extracellular cues, which guide them through intermediate steps and onto final synaptic target sites.
Massimo M. Onesto +4 more
doaj +1 more source
Adaptive Mesh Refinement Computation of Solidification Microstructures using Dynamic Data Structures
, 1998 We study the evolution of solidification microstructures using a phase-field model computed on an adaptive, finite element grid. We discuss the details of our algorithm and show that it greatly reduces the computational cost of solving the phase-field ...
Almgren +44 more
core +2 more sources
Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]
, 2006 Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M. +3 more
core +2 more sources
Dendritic compactifications of certain dendritic spaces [PDF]
Pacific Journal of Mathematics, 1973 A dendritic space is a connected space in which every two points are separated by a third point. In this paper we describe a very natural method for obtaining a dendritic compactification of any connected space for which a dendritic compactification exists.
openaire +3 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Electrocrystallization of fibrous silver deposits from nitrate melts: Experiments and modeling [PDF]
Journal of Mining and Metallurgy. Section B: Metallurgy, 2003 Fibrous silver deposits have been obtained in molten nitrates on a moving cathode. Cylindrical silver cathode was lifted from the melt AgNO3-NaNO3-KNO3. It is found that the dimensions of the silver threads as well as their shape and thickness depend on ...
Murashova I.B. +4 more
doaj +1 more source
Cortical patterns and gamma genesis are modulated by reversal potentials and gap-junction diffusion [PDF]
, 2010 In this chapter we describe a continuum model for the cortex that includes both axon-to-dendrite chemical synapses and direct neuron-to-neuron gap-junction diffusive synapses.
Sleigh, James W. +3 more
core +2 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Frontiers in Molecular Neuroscience, 2023 IntroductionAnkG, encoded by the ANK3 gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node of Ranvier, whereas the 190 kDa isoform (AnkG-190) has an ...
Nicolas H. Piguel +11 more
doaj +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source