Results 91 to 100 of about 284,053 (380)

Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines

eLife, 2017
Neurons face the challenge of regulating the abundance, distribution and repertoire of integral membrane proteins within their immense, architecturally complex dendritic arbors.
Aaron B Bowen, Ashley M. Bourke, Brian G. Hiester, Cyril Hanus, M. Kennedy   +4 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Autologous nerve graft repair of different degrees of sciatic nerve defect: stress and displacement at the anastomosis in a three-dimensional fnite element simulation model

Neural Regeneration Research, 2015
In the repair of peripheral nerve injury using autologous or synthetic nerve grafting, the magnitude of tensile forces at the anastomosis affects its response to physiological stress and the ultimate success of the treatment.
Cheng-dong Piao, Kun Yang, Peng Li, Min Luo   +3 more
doaj   +1 more source

Patronin-mediated minus end growth is required for dendritic microtubule polarity. [PDF]

, 2019
Microtubule minus ends are thought to be stable in cells. Surprisingly, in Drosophila and zebrafish neurons, we observed persistent minus end growth, with runs lasting over 10 min.
Albertson, Richard M, Feng, Chengye, Goetschius, Daniel J, Rao, Kavitha S, Rolls, Melissa M, Sagasti, Alvaro, Seebold, Dylan Y, Shorey, Matthew, Thyagarajan, Pankajam, Weiner, Alexis T   +9 more
core   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Early Effects of Aβ Oligomers on Dendritic Spine Dynamics and Arborization in Hippocampal Neurons

Frontiers in Synaptic Neuroscience, 2020
Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to impaired memory and cognitive deficits. Spine loss as well as changes in spine morphology correlates with cognitive impairment in this neurological disorder.
Carolina Ortiz-Sanz, Carolina Ortiz-Sanz, Adhara Gaminde-Blasco, Adhara Gaminde-Blasco, Jorge Valero, Jorge Valero, Lidia Bakota, Roland Brandt, Roland Brandt, Roland Brandt, José L. Zugaza, José L. Zugaza, José L. Zugaza, Carlos Matute, Carlos Matute, Elena Alberdi, Elena Alberdi   +16 more
doaj   +1 more source

Branching dendrites with resonant membrane: a “sum-over-trips” approach [PDF]

, 2007
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons.
A Mauro, A Ooyen van, A Scott, AJ Hudspeth, B Hutcheon, B Hutcheon, BJ Cao, C Koch, C Koch, C. -M. Svensson, C. M. Colbert, D Johnson, EG Butz, G. J. Lord, HC Pape, HC Tuckwell, I Segev, JC Magee, JD Evans, JD Evans, K. Josić, LF Abbott, LF Abbott, M Häusser, M London, M London, M Migliore, MHP Kole, NT Carnevale, S. Coombes, S. J. Cox, SJ Cox, SJ Cox, X Li, Y Timofeeva, Y Timofeeva, Y. Timofeeva, ZF Mainen   +37 more
core   +3 more sources

Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation

Journal of Neuroscience, 2016
In cultured vertebrate neurons, axons have a uniform arrangement of microtubules with plus-ends distal to the cell body (plus-end-out), whereas dendrites contain mixed polarity orientations with both plus-end-out and minus-end-out oriented microtubules ...
K. Yau, P. Schätzle, Elena Tortosa, S. Pagès, A. Holtmaat, L. Kapitein, C. Hoogenraad   +6 more
semanticscholar   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Optimal sizes of dendritic and axonal arbors in a topographic projection

, 1999
I consider a topographic projection between two neuronal layers with different densities of neurons. Given the number of output neurons connected to each input neuron (divergence) and the number of input neurons synapsing on each output neuron ...
Chklovskii, Dmitri B.
core   +2 more sources