MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis [PDF]
BMC Immunology, 2018 Background Splenic stroma overlaid with hematopoietic progenitors supports in vitro hematopoiesis with production of dendritic-like cells. Co-cultures of murine lineage-depleted bone marrow over the 5G3 stromal line produce two populations of cells ...
Sawang Petvises +2 more
doaj +4 more sources
Dendritic Cell Subsets in Intestinal Immunity and Inflammation [PDF]
The Journal of Immunology, 2020 The mammalian intestine is a complex environment that is constantly exposed to Ags derived from food, microbiota, and metabolites. Intestinal dendritic cells (DC) have the responsibility of establishing oral tolerance against these Ags while initiating ...
Tian Sun, A. Nguyen, J. Gommerman
semanticscholar +3 more sources
Distinct dendritic cell subsets actively induce Th2 polarization [PDF]
Current Opinion in Immunology, 2014 The mechanisms by which dendritic cells induce Th2 polarization (DC(Th2) cells) have been controversial. Many have argued that DC(Th2) cells are not a distinct functional DC subset, but rather, DC-induced polarization of Th2 cells is a default pathway that occurs in the absence of inflammatory signals leading to DC-induced polarization of Th1/Th17 ...
Melissa Y. Tjota, Anne I. Sperling
openalex +3 more sources
Subsets of CD1c+ DCs: Dendritic Cell Versus Monocyte Lineage
Frontiers in Immunology, 2020 Currently three bona fide dendritic cell (DC) types are distinguished in human blood. Herein we focus on type 2 DCs (DC2s) and compare the three defining markers CD1c, CD172, and CD301.
Lukas Heger +10 more
doaj +2 more sources
Development and function of dendritic cell subsets. [PDF]
Immunity, 2014 Classical dendritic cells (cDCs) form a critical interface between innate and adaptive immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of pathogen challenges and cancer. They translate the latter for T cells into peptide form.
A. Mildner, Steffen Jung
semanticscholar +3 more sources
Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets [PDF]
Frontiers in Immunology, 2022 Helminths produce excretory/secretory products (E/S) which can modulate the immune responses of their hosts. Dendritic cells (DC) are essential for initiating the host T cell response and are thus potential targets for modulation by helminth E/S. Here we
Benjamin Hamid +5 more
doaj +2 more sources
Metronidazole Treatment Failure and Persistent BV Lead to Increased Frequencies of Activated T- and Dendritic-Cell Subsets [PDF]
Microorganisms, 2023 Metronidazole (MDZ) treatment failure and bacterial vaginosis (BV) recurrence rates are high among African women. This cohort study identified genital immune parameters associated with treatment response by comparing vaginal microbiota and immune cell ...
Wenkosi Perez Qulu +13 more
doaj +2 more sources
Immunology, 2013 Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages.
M. Collin, N. McGovern, M. Haniffa
semanticscholar +4 more sources
Myelin-reactive CD8+ T cells influence conventional dendritic cell subsets towards a mature and regulatory phenotype in experimental autoimmune encephalomyelitis [PDF]
Journal of NeuroinflammationMultiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system, is modeled in mice as experimental autoimmune encephalomyelitis (EAE).
Mohit Upadhye +7 more
doaj +2 more sources
Correlation analysis between peripheral blood dendritic cell subsets and PD-1 in patients with peritoneal adenocarcinoma [PDF]
Brazilian Journal of Medical and Biological ResearchThe aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of ...
Huihui Hu, Man Zhang
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