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Migration of dendritic cell subsets
2006DC are professional APC. To accomplish their biological functions, they need to go through a complex pattern of migration, which includes their localization to both peripheral non-lymphoid tissues and secondary lymphoid organs. In the absence of correct tissue localization, DC fail to promote proper immune responses.
SOZZANI, Silvano +5 more
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Dendritic Cell Subsets and Toll-Like Receptors
2008Toll-like receptors exist as highly conserved pathogen sensors throughout the animal kingdom and they represent a key family of molecules bridging the ancient innate and adaptive immune systems. The first molecules of adaptive immunity appeared in the cartilaginous fishes and, with these, major histocompatibility proteins and cells expressing these ...
Hubertus, Hochrein, Meredith, O'Keeffe
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Isolation of Conventional Murine Lung Dendritic Cell Subsets
Current Protocols in Immunology, 2018AbstractThe lungs are continuously exposed to environmental threats, requiring an adequate and stringent immune response of a heterogeneous set of effector cells. Dendritic cells (DCs) form a dense network in the respiratory mucosa and act as the central regulators of the different components of this response, both sensing the nature of the threats and
Cédric, Bosteels +2 more
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Isolation of Conventional Murine Lung Dendritic Cell Subsets
2022In the lungs, immune cells make contact with different antigens every day. This requires an adequate immune response. Dendritic cells (DCs) form a dense network in the respiratory mucosa and continuously sample inhaled allergens. They play an important role in bridging innate and adaptive immunity.
Elisabeth, De Leeuw +3 more
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A dendritic cell subset designed for oral tolerance
Nature Immunology, 2016Studies using genetic tools have identified the distinct dendritic cell subsets that ensure tolerance to oral antigens in the antigen-rich environment of the gut and suggest a 'division of labor' for protective immunity.
Reinhard, Hinterleitner, Bana, Jabri
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Regulation of alloimmune responses by dendritic cell subsets
Experimental Hematology, 2008Dendritic cells (DCs) are powerful mediators of immune responses. We have demonstrated that the content of plasmacytoid (type 2) dendritic cells (DC2) within allogeneic bone marrow grafts impacts survival and graft-vs-host disease following transplantation.
Sagar, Lonial +5 more
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Clinical Analysis of Dendritic Cell Subsets
2008Dendritic cells (DCs) are crucial in adaptive immunity because they are the only antigen-presenting cells that can present antigens to naive T lymphocytes. Plasmacytoid DCs (pDC) are also the main producers of type I Interferons in response to infection.
Anne Hosmalin +2 more
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Phenotype and function of rat dendritic cell subsets
APMIS, 2003Dendritic cells (DC) comprise phenotypically‐distinct subsets that sub‐serve distinct functions in immune induction. Understanding the biology of DC subsets in vivo is crucial for the understanding of immune regulation and its perturbations in disease. This review focuses on the phenotype and functions of rat DC subsets and compares these with subsets ...
Ulf, Yrlid, Gordon, Macpherson
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Dendritic Cell Subsets and Immune Regulation
2011Dendritic cells (DC) are efficient antigen presenting cells. They represent a dynamic network in the immune system and can collect and process antigens for presentation to T cells. Although all can present antigens, DC differ in the additional regulatory signals they transmit to direct T cells to different types of immune responses or to tolerance ...
Meredith O’Keeffe +3 more
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Migration of Dendritic Cell Subsets and their Precursors
Annual Review of Immunology, 2008The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a consequence of their localization within tissues and their specialized capacity for mobilization. The migration of a given DC subset is typified by a restricted capacity for recirculation, contrasting markedly with T cells.
Gwendalyn J, Randolph +2 more
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