Results 91 to 100 of about 95,281 (299)
Biological Research, 2023 Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain.
Qiaoyun Wu +10 more
doaj +1 more source
A watershed and active contours based method for dendritic spine segmentation in 2-photon microscopy images (2-Foton mikroskopi görüntülerindeki dendritik dikenlerin bölütlenmesi için watershed ve etkin çevritlere dayalı bir yöntem) [PDF]
, 2013 Analysing morphological and volumetric properties of dendritic spines from 2-photon microscopy images has been of interest to neuroscientists in recent years. Developing robust and reliable tools for automatic analysis depends on the segmentation quality.
Argunsah, Ali Ozgur +7 more
core +1 more source
Actin cytoskeleton in dendritic spine
Folia Pharmacologica Japonica, 2007 樹状突起スパインは脳内の主要な興奮性シナプス後部であり，その形態および構成タンパク質の可塑的変化は学習記憶などの高次機能に重要である．スパイン内の構造体としては，シナプス後部肥厚（PSD）とアクチン細胞骨格があり，スパインの形態変化は主にアクチン細胞骨格により制御されている．スパイン内ではその頭部と頸部でアクチン線維の構造が異なることに加えて，頭部の中でもシナプス直下のPSD近傍と細胞質の中心領域でアクチン結合タンパク質の分布が異なる．したがって，スパインは3種類の性質の異なるアクチン細胞骨格によって構成されていると考えられる．アクチンを脱重合させると，多くのスパイン構成タンパク質の局在が不安定化し，スパイン形態もフィロポディア様に変化する．従って，アクチン細胞骨格がスパイン形態の形成 ...
Kenji, Hanamura, Tomoaki, Shirao
openaire +3 more sources
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit [PDF]
, 2016 Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction.
Caioli, Silvia +5 more
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Subtype-specific plasticity of inhibitory circuits in motor cortex during motor learning. [PDF]
, 2015 Motor skill learning induces long-lasting reorganization of dendritic spines, principal sites of excitatory synapses, in the motor cortex. However, mechanisms that regulate these excitatory synaptic changes remain poorly understood.
Chen, Simon X +3 more
core
Protein synthesis at synaptic sites on dendrites [PDF]
, 2001 Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
core +1 more source
Advanced Science, EarlyView.We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin +10 more
wiley +1 more source
Dendritic Spine and Synaptic Plasticity in Alzheimer’s Disease: A Focus on MicroRNA
Frontiers in Cell and Developmental Biology, 2020 Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity and have been recognized as the locus of long-term synaptic plasticity related to cognitive processes such as learning and memory.
Edwin Estefan Reza-Zaldivar +8 more
doaj +1 more source