Results 111 to 120 of about 58,744 (263)

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Infinite Functional Versatility, Formidable Limits: Evaluating Gallium‐Based Liquid Metals in Rechargeable Batteries

Carbon Energy, EarlyView.
Beyond the hype surrounding the self‐healing properties of gallium‐based liquid metals (Ga‐LMs), this perspective critically examines their functional roles in metal‐ion batteries, highlighting both their underlying merits and the often‐overlooked challenges, including non‐representative design and testing configurations, performance overestimations ...
Turly P. P. Sumanasekara, Petar Jovanović, Ali Zavabeti, Dan Yang, Mainak Majumder, Anthony F. Hollenkamp, Torben Daeneke, Mahdokht Shaibani   +7 more
wiley   +1 more source

Hyperactive KIF5A in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos, James N. Sleigh   +1 more
wiley   +1 more source

Recovery and Repurposing of End‐of‐Life Graphitic Anodes for Green Lithium‐Ion Batteries

EcoEnergy, EarlyView.
This review summarizes the degradation mechanisms of spent graphite anodes in lithium‐ion batteries and highlights key recycling, regeneration, and modification strategies, including hydrometallurgical and pyrometallurgical approaches. It also discusses recent advances in surface engineering, structural regulation, and material hybridization, offering ...
Wei Wei, Weiguo Liu, Jiangqi Zhou
wiley   +1 more source

Heterogeneous Single/Dual‐Atom Electrocatalysts in Lithium–Sulfur Batteries

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review summarizes recent advances in single‐atom and dual‐atom electrocatalysts for high‐performance lithium–sulfur batteries. The text systematically covers the classification of catalysts by active metal centers, key synthesis methods, in situ characterization for mechanistic insights, and electrocatalytic mechanisms.
Wenbin Li, Ying Xin, Zhaoliang Zhang, Jin Wang   +3 more
wiley   +1 more source

Anode/Electrolyte Interfacial Engineering Toward Sustainable and Practical Solid‐State Metal‐Sulfur Batteries: A Prospective Review

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Coordinated engineering of the anode, electrolyte, and interface underpins the rational design of next‐generation solid‐state metal‐sulfur batteries. Solid‐state metal‐sulfur batteries are emerging as a transformative energy storage platform with the potential to overcome the fundamental limitations of conventional flooded cells, particularly ...
Ziyu Feng, Hong Zhang, Peng Wang, Ke Lu, Fei Du   +4 more
wiley   +1 more source

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

Arthritis &Rheumatology, EarlyView.
Kerem Abacar, Ala Altaie, Andrew Barr, Sarah L. Mackie, Kulveer Mankia, Dennis McGonagle   +5 more
wiley   +1 more source

Advances in Design Strategy and Mechanism Insights for Alkaline Hydrogen Evolution Reaction: Multilevel Site Engineering and Structure–Activity Relationship

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review is about material design based on engineering multilevel sites from theoretical calculation and synthetic routes to mechanism, structure–activity relationship, challenges and perspectives for boosting hydrogen production in alkaline electrolyte. Electrolytic water splitting is a clean, carbon‐free method for producing green hydrogen and has
Ke Zhang, Hongying Luo, Yudong Du, Kehao Yu, Huayu Wu, Shimin Chai, Yanyan Liu, Yongfeng Wang, Jianchun Jiang, Baojun Li   +9 more
wiley   +1 more source