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Genetic deletion of zinc transporter ZnT3 induces progressive cognitive deficits in mice by impairing dendritic spine plasticity and glucose metabolism. [PDF]
Zong R+9 more
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α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrP<sup>C</sup>-CCR5 dependent pathway. [PDF]
Oliveira da Silva MI+14 more
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Kamishoyosan Normalizes Dendritic Spine Morphology in the Medial Prefrontal Cortex by Regulating microRNA-18 and Glucocorticoid Receptor Expressions in Postmenopausal Chronic Stress-Exposed Mice. [PDF]
Shimizu S+6 more
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Annual Review of Physiology, 2009
Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
Shengxiang Zhang+2 more
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Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
Shengxiang Zhang+2 more
openaire +3 more sources
Microtubules, dendritic spines and spine apparatuses
Cell and Tissue Research, 1980Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic "thickening" in primordial spines and with the dense "plate ...
Lesnick E. Westrum+7 more
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2014
Fragile X syndrome is a mental condition caused by the mutation in a single gene called the fragile X mental retardation 1 (FMR1) gene, which is found on the X chromosome. Fragile X syndrome is the most common inherited condition causing mental retardation. Fragile X syndrome can cause learning disabilities, severe mental incapacitation and even autism.
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Fragile X syndrome is a mental condition caused by the mutation in a single gene called the fragile X mental retardation 1 (FMR1) gene, which is found on the X chromosome. Fragile X syndrome is the most common inherited condition causing mental retardation. Fragile X syndrome can cause learning disabilities, severe mental incapacitation and even autism.
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Microtubule Dynamics in Dendritic Spines
2010Neuronal microtubules recently emerged as temporal and spatial regulators of dendritic spines, the major sites of excitatory synaptic input. By imaging microtubules in cultured mature primary hippocampal neurons using fluorescently tagged tubulin and microtubule plus-end binding (EB) protein EB3, dynamic microtubules were found to regularly depart from
Lukas C. Kapitein+2 more
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Dendritic spine formation and stabilization
Current Opinion in Neurobiology, 2009Formation, elimination and remodeling of excitatory synapses on dendritic spines represent a continuous process that shapes the organization of synaptic networks during development. The molecular mechanisms controlling dendritic spine formation and stabilization therefore critically determine the rules of network selectivity.
Yoshihara, Yoshihiro+2 more
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