Results 211 to 220 of about 87,585 (230)
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Regulation of dendritic spine stability
Hippocampus, 2000Dendritic spines undergo several types of transformations, ranging from growth to collapse, and from elongation to shortening, and they experience dynamic morphological activity on a rapid time scale. Changes in spine number and morphology occur under pathological conditions like excitotoxicity, but also during normal central nervous system development,
Shelley Halpain, Fiona M. Smart
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Book Review: On the Function of Dendritic Spines
The Neuroscientist, 2001Dendritic spines occupy a strategic position in the central nervous system, yet their function is still under debate. Over the past decades, many hypotheses have been put forward to explain the specific function of spines. Recently, imaging experiments have demonstrated that spines compartmentalize calcium, a role that appears necessary for input ...
Ania K. Majewska, Rafael Yuste
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Dendrite and dendritic spine alterations in alzheimer models
Journal of Neurocytology, 2004Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients. Multicolor DiOlistic labeling of the hippocampus has been undertaken which allows the full dendritic arbor of targeted neurons to be imaged.
Ottavio V. Vitolo +3 more
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Dendritic spine morphogenesis and plasticity
Journal of Neurobiology, 2005AbstractDendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts.
Lippman-Bell, Jocelyn, Dunaevsky, A.
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Structure and Function of Dendritic Spines
Annual Review of Physiology, 2002▪ Abstract  Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines.
Bernardo L. Sabatini +2 more
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Electrical Compartmentalization in Dendritic Spines [PDF]
Annual Review of Neuroscience, 2013 Most excitatory inputs in the CNS contact dendritic spines, avoiding dendritic shafts, so spines must play a key role for neurons. Recent data suggest that, in addition to enhancing connectivity and isolating synaptic biochemistry, spines can behave as electrical compartments independent from their parent dendrites. It is becoming clear that, although
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On the electrical function of dendritic spines
Trends in Neurosciences, 2004Dendritic spines mediate most excitatory inputs in the brain, yet their function is still unclear. Imaging experiments have demonstrated their role in biochemical compartmentalization at individual synapses, yet theoretical studies have suggested that they could serve an electrical function in transforming synaptic inputs and transmitting dendritic ...
Rafael Yuste, David Tsay
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Dynamics and pathology of dendritic spines
2005Dendritic spines are key players in information processing in the brain. Changes in spine shape and wholesale spine turnover provide mechanisms for modifying existing synaptic connections and altering neuronal connectivity. Although neuronal cell death in acute and chronic neurodegenerative diseases is clearly an important factor in decline of ...
Shelley Halpain +2 more
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Science, 2001
STKE Changes in the morphology of neuronal dendritic spines are correlated with changes in synaptic plasticity. The cell surface proteoglycan syndecan-2 is clustered at the surface of mature hippocampal neurons and is thought to regulate structural changes of the spines. Now Ethell et al.
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STKE Changes in the morphology of neuronal dendritic spines are correlated with changes in synaptic plasticity. The cell surface proteoglycan syndecan-2 is clustered at the surface of mature hippocampal neurons and is thought to regulate structural changes of the spines. Now Ethell et al.
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Molecular morphogens for dendritic spines
Trends in Neurosciences, 2002Three protein components of the postsynaptic density--Shank, Homer and SPAR--have been found to regulate the structural and molecular organization of dendritic spines. These new studies reveal linkages between receptor complexes, the actin cytoskeleton and signaling molecules that help shape spines.
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