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Expression of Concern: Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease. [PDF]
Hum Mol Geneteuropepmc +1 more source
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Annual Review of Physiology, 2009
Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
Shengxiang Zhang, Wen-Biao Gan
exaly +3 more sources
Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
Shengxiang Zhang, Wen-Biao Gan
exaly +3 more sources
Microtubules, dendritic spines and spine apparatuses
Cell and Tissue Research, 1980Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic "thickening" in primordial spines and with the dense "plate ...
L E, Westrum +3 more
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Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», 2022
Мозг осуществляет постоянное и чаще достаточно успешное приспособление организма к меняющимся условиям среды. Важнейшим структурно-функциональным проявлением этой приспособительной реакции мозга является адекватное ситуации изменение числа, внешней формы, внутреннего строения, скорости структурных перестроек, химического состава воспринимающих сигнал ...
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Мозг осуществляет постоянное и чаще достаточно успешное приспособление организма к меняющимся условиям среды. Важнейшим структурно-функциональным проявлением этой приспособительной реакции мозга является адекватное ситуации изменение числа, внешней формы, внутреннего строения, скорости структурных перестроек, химического состава воспринимающих сигнал ...
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Dendritic Spines and Pain Memory
The Neuroscientist, 2022Neuropathic pain is a debilitating form of pain arising from injury or disease of the nervous system that affects millions of people worldwide. Despite its prevalence, the underlying mechanisms of neuropathic pain are still not fully understood. Dendritic spines are small protrusions on the surface of neurons that play an important role in synaptic ...
Curtis A. Benson +5 more
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Microtubule Dynamics in Dendritic Spines
2010Neuronal microtubules recently emerged as temporal and spatial regulators of dendritic spines, the major sites of excitatory synaptic input. By imaging microtubules in cultured mature primary hippocampal neurons using fluorescently tagged tubulin and microtubule plus-end binding (EB) protein EB3, dynamic microtubules were found to regularly depart from
Kapitein, Lukas +2 more
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Dendrite and dendritic spine alterations in alzheimer models
Journal of Neurocytology, 2004Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients. Multicolor DiOlistic labeling of the hippocampus has been undertaken which allows the full dendritic arbor of targeted neurons to be imaged.
Donna L, Moolman +3 more
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