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The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity
The Neuroscientist, 2010The spine apparatus (SA) is an essential component of mature dendritic spines of cortical and hippocampal neurons, yet its functions are still enigmatic. Synaptopodin (SP), an actin-binding protein, colocalizes with the SA. Hippocampal neurons in SP-knockout mice lack SA, and they express lower LTP. SP probably plays a role in synaptic plasticity, but
Menahem, Segal +2 more
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On the electrical function of dendritic spines
Trends in Neurosciences, 2004Dendritic spines mediate most excitatory inputs in the brain, yet their function is still unclear. Imaging experiments have demonstrated their role in biochemical compartmentalization at individual synapses, yet theoretical studies have suggested that they could serve an electrical function in transforming synaptic inputs and transmitting dendritic ...
David, Tsay, Rafael, Yuste
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Electrical properties of dendritic spines
Biophysical Journal, 2023Dendritic spines are small protrusions that mediate most of the excitatory synaptic transmission in the brain. Initially, the anatomical structure of spines has suggested that they serve as isolated biochemical and electrical compartments. Indeed, following ample experimental evidence, it is now widely accepted that a significant physiological role of ...
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Dendritic spines and linear networks
Journal of Physiology-Paris, 2004The function of the cortical microcircuitry is still mysterious. Using a bottom-up analysis based on the biophysics and connectivity of cortical neurons, we propose the hypothesis that the neocortex is essentially a linear integrator of inputs. Dendritic spines would slow the neuron and contribute to linearize input summation.
Rafael, Yuste, Rochelle, Urban
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Dynamics and pathology of dendritic spines
2005Dendritic spines are key players in information processing in the brain. Changes in spine shape and wholesale spine turnover provide mechanisms for modifying existing synaptic connections and altering neuronal connectivity. Although neuronal cell death in acute and chronic neurodegenerative diseases is clearly an important factor in decline of ...
Shelley, Halpain +2 more
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Dendritic spine formation and stabilization
Current Opinion in Neurobiology, 2009Formation, elimination and remodeling of excitatory synapses on dendritic spines represent a continuous process that shapes the organization of synaptic networks during development. The molecular mechanisms controlling dendritic spine formation and stabilization therefore critically determine the rules of network selectivity.
Yoshihara, Yoshihiro +2 more
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Structure and Function of Dendritic Spines
Annual Review of Physiology, 2002▪ Abstract Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines.
Esther A, Nimchinsky +2 more
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Dendritic spine morphogenesis and plasticity
Journal of Neurobiology, 2005AbstractDendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts.
Lippman-Bell, Jocelyn, Dunaevsky, A.
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1998
Dendritic spines, sometimes also called dendritic thorns, are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramón y Cajal (1909; 1991) in light-microscopic studies of Golgi stained tissue, they are among the most striking subneuronal features of many neurons.
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Dendritic spines, sometimes also called dendritic thorns, are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramón y Cajal (1909; 1991) in light-microscopic studies of Golgi stained tissue, they are among the most striking subneuronal features of many neurons.
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2010
A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on
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A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on
openaire +1 more source