Results 151 to 160 of about 71,138 (196)

Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor. [PDF]

Transl Psychiatry
Vandael D, Vints K, Baatsen P, Śliwińska MA, Gabarre S, De Groef L, Moons L, Rybakin V, Gounko NV.   +8 more
europepmc   +1 more source

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Dendritic Spine Dynamics

Annual Review of Physiology, 2009
Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
D Harshad, Bhatt, Shengxiang, Zhang, Wen-Biao, Gan   +2 more
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Microtubules, dendritic spines and spine apparatuses

Cell and Tissue Research, 1980
Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic "thickening" in primordial spines and with the dense "plate ...
L E, Westrum, D H, Jones, E G, Gray, J, Barron   +3 more
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Spines of dendrites

Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», 2022
Мозг осуществляет постоянное и чаще достаточно успешное приспособление организма к меняющимся условиям среды. Важнейшим структурно-функциональным проявлением этой приспособительной реакции мозга является адекватное ситуации изменение числа, внешней формы, внутреннего строения, скорости структурных перестроек, химического состава воспринимающих сигнал ...
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Dendritic Spines and Pain Memory

The Neuroscientist, 2022
Neuropathic pain is a debilitating form of pain arising from injury or disease of the nervous system that affects millions of people worldwide. Despite its prevalence, the underlying mechanisms of neuropathic pain are still not fully understood. Dendritic spines are small protrusions on the surface of neurons that play an important role in synaptic ...
Curtis A. Benson, Jared F. King, Marike L. Reimer, Sierra D. Kauer, Stephen G. Waxman, Andrew M. Tan   +5 more
openaire   +2 more sources

Microtubule Dynamics in Dendritic Spines

2010
Neuronal microtubules recently emerged as temporal and spatial regulators of dendritic spines, the major sites of excitatory synaptic input. By imaging microtubules in cultured mature primary hippocampal neurons using fluorescently tagged tubulin and microtubule plus-end binding (EB) protein EB3, dynamic microtubules were found to regularly depart from
Kapitein, Lukas, Yau, Kah wai, Hoogenraad, CC   +2 more
openaire   +3 more sources

Dendrite and dendritic spine alterations in alzheimer models

Journal of Neurocytology, 2004
Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients. Multicolor DiOlistic labeling of the hippocampus has been undertaken which allows the full dendritic arbor of targeted neurons to be imaged.
Donna L, Moolman, Ottavio V, Vitolo, Jean-Paul G, Vonsattel, Michael L, Shelanski   +3 more
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The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity

The Neuroscientist, 2010
The spine apparatus (SA) is an essential component of mature dendritic spines of cortical and hippocampal neurons, yet its functions are still enigmatic. Synaptopodin (SP), an actin-binding protein, colocalizes with the SA. Hippocampal neurons in SP-knockout mice lack SA, and they express lower LTP. SP probably plays a role in synaptic plasticity, but
Menahem, Segal, Andreas, Vlachos, Eduard, Korkotian   +2 more
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On the electrical function of dendritic spines

Trends in Neurosciences, 2004
Dendritic spines mediate most excitatory inputs in the brain, yet their function is still unclear. Imaging experiments have demonstrated their role in biochemical compartmentalization at individual synapses, yet theoretical studies have suggested that they could serve an electrical function in transforming synaptic inputs and transmitting dendritic ...
David, Tsay, Rafael, Yuste
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Dendritic spines and linear networks

Journal of Physiology-Paris, 2004
The function of the cortical microcircuitry is still mysterious. Using a bottom-up analysis based on the biophysics and connectivity of cortical neurons, we propose the hypothesis that the neocortex is essentially a linear integrator of inputs. Dendritic spines would slow the neuron and contribute to linearize input summation.
Rafael, Yuste, Rochelle, Urban
openaire   +2 more sources