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Annual Review of Physiology, 2009
Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
Shengxiang Zhang +2 more
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Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
Shengxiang Zhang +2 more
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Microtubules, dendritic spines and spine apparatuses
Cell and Tissue Research, 1980Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic "thickening" in primordial spines and with the dense "plate ...
Lesnick E. Westrum +7 more
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2014
Fragile X syndrome is a mental condition caused by the mutation in a single gene called the fragile X mental retardation 1 (FMR1) gene, which is found on the X chromosome. Fragile X syndrome is the most common inherited condition causing mental retardation. Fragile X syndrome can cause learning disabilities, severe mental incapacitation and even autism.
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Fragile X syndrome is a mental condition caused by the mutation in a single gene called the fragile X mental retardation 1 (FMR1) gene, which is found on the X chromosome. Fragile X syndrome is the most common inherited condition causing mental retardation. Fragile X syndrome can cause learning disabilities, severe mental incapacitation and even autism.
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Detection of Dendritic Spines Using Wavelet Packet Entropy and Fuzzy Support Vector Machine.
CNS and Neurological Disorders - Drug Targets, 2017The morphology of dendritic spines is highly correlated with the neuron function. Therefore, it is of positive influence for the research of the dendritic spines. However, it is tried to manually label the spine types for statistical analysis.
Shuihua Wang +5 more
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Microtubule Dynamics in Dendritic Spines
2010Neuronal microtubules recently emerged as temporal and spatial regulators of dendritic spines, the major sites of excitatory synaptic input. By imaging microtubules in cultured mature primary hippocampal neurons using fluorescently tagged tubulin and microtubule plus-end binding (EB) protein EB3, dynamic microtubules were found to regularly depart from
Lukas C. Kapitein +2 more
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Dendritic spine formation and stabilization
Current Opinion in Neurobiology, 2009Formation, elimination and remodeling of excitatory synapses on dendritic spines represent a continuous process that shapes the organization of synaptic networks during development. The molecular mechanisms controlling dendritic spine formation and stabilization therefore critically determine the rules of network selectivity.
Yoshihara, Yoshihiro +2 more
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Regulation of dendritic spine stability
Hippocampus, 2000Dendritic spines undergo several types of transformations, ranging from growth to collapse, and from elongation to shortening, and they experience dynamic morphological activity on a rapid time scale. Changes in spine number and morphology occur under pathological conditions like excitotoxicity, but also during normal central nervous system development,
Shelley Halpain, Fiona M. Smart
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Book Review: On the Function of Dendritic Spines
The Neuroscientist, 2001Dendritic spines occupy a strategic position in the central nervous system, yet their function is still under debate. Over the past decades, many hypotheses have been put forward to explain the specific function of spines. Recently, imaging experiments have demonstrated that spines compartmentalize calcium, a role that appears necessary for input ...
Ania K. Majewska, Rafael Yuste
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Dendrite and dendritic spine alterations in alzheimer models
Journal of Neurocytology, 2004Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients. Multicolor DiOlistic labeling of the hippocampus has been undertaken which allows the full dendritic arbor of targeted neurons to be imaged.
Ottavio V. Vitolo +3 more
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